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G9880

Sigma-Aldrich

Glutamic-Pyruvic Transaminase from porcine heart

ammonium sulfate suspension, ≥75 units/mg protein

Synonyme(s) :

ALT1, L-Alanine: 2-Oxoglutarate Aminotransferase, Alanine Aminotransferase (catalytic concentration), GPT

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About This Item

Numéro CAS:
9000-86-6
Numéro de classification (Commission des enzymes):
2.6.1.2 (BRENDA, IUBMB)
Beilstein:
3562140
Numéro CE :
232-561-4
Numéro MDL:
MFCD00131192
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.54

Source biologique

Porcine heart

Niveau de qualité

200

Forme

ammonium sulfate suspension

Activité spécifique

≥75 units/mg protein

Poids mol.

42 kDa

Activité étrangère

L-glutamic dehydrogenase, lactic dehydrogenase and malic dehydrogenase ≤0.01%
glutamic-oxalacetic transaminase ≤0.05%

Conditions d'expédition

wet ice

Température de stockage

2-8°C

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Description générale

Research area: Cell Signaling
Glutamic-pyruvic transaminase (GPT) is located in most cells in the body but is found in highest concentrations in the liver. Two GPT isoforms, GPT1 and GPT2, are present in mammals.

Application

Glutamic-Pyruvic Transaminase from porcine heart has been used to determine L-lactate levels in aqueous polyethylene glycol (PEG) solutions.

Actions biochimiques/physiologiques

GPT is responsible for catalyzing the reversible transamination of α-ketoglutarate and alanine to glutamate and pyruvate. It also plays a critical role in the metabolism of amino acids and gluconeogenesis.
Glutamic-pyruvic transaminase (GPT) is located in most cells in the body, but is found in highest concentrations in the liver. It is used as a marker of liver disease due to the release of GPT into the blood following liver cell necrosis.

Définition de l'unité

One unit will convert 1.0 μmole of α-ketoglutarate to L-glutamate per min at pH 7.6 at 37 °C in the presence of L-alanine.

Forme physique

Suspension in 1.8 M (NH4)2SO4 solution, pH 6.0

Remarque sur l'analyse

Protein determined by biuret.

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H334

Conseils de prudence

P261 - P284 - P501

Classification des risques

Resp. Sens. 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
SLCG1694
SLCD2943
SLBD6656V
SLBP5543V
SLBF9258V

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Consulter la Bibliothèque de documents

M A Mahtab et al.
Bangladesh Medical Research Council bulletin, 38(3), 104-107 (2013-04-02)
Hepatitis B surface antigen (HBsAg) is regarded as sole marker of hepatitis B virus (HBV) infection in Bangladesh and most other developing countries. However, some HBV-negative subjects may harbor HBV DNA and transfusion of their blood may cause HBV infection
Martin J J Ronis et al.
Experimental biology and medicine (Maywood, N.J.), 238(2), 151-162 (2013-04-12)
Metabolic syndrome is often accompanied by development of hepatic steatosis and less frequently by non-alcoholic fatty liver disease (NAFLD) leading to non-alcoholic steatohepatitis (NASH). Replacement of corn oil with medium chain triacylglycerols (MCT) in the diets of alcohol-fed rats has
Hua Du
Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control, 25(1), 115-115 (2013-05-22)
To discuss the relationship between advanced schistosomiasis and HBV infection. A total of 250 advanced schistosomiasis patients were examined with ultrasound, and their serum samples were detected for liver function, HBsAg, etc. The correlations between HBV infection and advanced types
Xing-Fei Pan et al.
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 26(6), 477-479 (2013-05-01)
To investigate the level of the serum IL-21 and its correlation with serum biochemical indices of liver function test in patients with acute-on-chronic liver failure. Sixty patients with acute-on-chronic liver failure (severe hepatitis group) and 18 normal cases (control group)
Antiviral immune response after live yellow fever vaccination of a kidney transplant recipient treated with IVIG.
Mark K Slifka et al.
Transplantation, 95(9), e59-e61 (2013-05-08)
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Instructions for working with enzymes supplied as ammonium sulfate suspensions

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