G8919
Anti-Growth Hormone Receptor antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonyme(s) :
Anti-GHR
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About This Item
Produits recommandés
Source biologique
goat
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
lyophilized powder
Espèces réactives
mouse
Technique(s)
immunohistochemistry: 5-15 μg/mL using cells and tissues
western blot: 0.1-0.2 μg/mL
Numéro d'accès UniProt
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
mouse ... Ghr(14600)
Description générale
By immunoblotting, this antibody shows ~50% cross-reactivity with recombinant rat GHR and 20% cross-reactivty with recombinant human GHR.
Growth Hormone Receptor encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of intra- and intercellular signal transduction pathways.
Immunogène
purified, NSO-derived, recombinant mouse growth hormone receptor extracellular domain.
Application
Anti-Growth Hormone Receptor antibody produced in goat was used to study the protein and protein phosphorylation levels in rat primary hippocampal cultures using Li-cor Odyssey fluorescence technology.
Actions biochimiques/physiologiques
Growth hormone (GH) is secreted by the anterior pituitary and functions by binding specific growth hormone receptor (GHR). GH stimulates the secretion of insulin-like growth factor-1 that mediates some of its growth promoting actions. The activity of GH/GHR is important for normal physiology and aging processes.
Forme physique
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
Certificats d'analyse (COA)
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Zhongbo Liu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(2), 635-652 (2015-10-21)
Bone minerals are acquired during growth and are key determinants of adult skeletal health. During puberty, the serum levels of growth hormone (GH) and its downstream effector IGF-1 increase and play critical roles in bone acquisition. The goal of the
Andrzej Bartke et al.
Endokrynologia Polska, 64(1), 46-52 (2013-03-02)
Studies in mutant, gene knock-out and transgenic mice have demonstrated that growth hormone (GH) signalling has a major impact on ageing and longevity. Growth hormone-resistant and GH-deficient animals live much longer than their normal siblings, while transgenic mice overexpressing GH
Marie-Laure Baudet et al.
Proteomics, 8(2), 389-401 (2008-01-19)
The possible presence and action of growth hormone (GH) in the neural retina was investigated in newborn mice. The neural retina was found to be a site of GH gene expression, as GH mRNA was abundant in cells of the
Juan Ding et al.
Proteomics, 13(3-4), 674-685 (2012-09-29)
Growth hormone (GH) is a protein secreted by the anterior pituitary and circulates throughout the body to exert important actions on growth and metabolism. GH stimulates the secretion of insulin-like growth factor-I (IGF-I) that mediates some of the growth promoting
George A Garinis et al.
Nature cell biology, 11(5), 604-615 (2009-04-14)
The accumulation of stochastic DNA damage throughout an organism's lifespan is thought to contribute to ageing. Conversely, ageing seems to be phenotypically reproducible and regulated through genetic pathways such as the insulin-like growth factor-1 (IGF-1) and growth hormone (GH) receptors
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