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G1506

Sigma-Aldrich

Guanylyl(3′→5′)cytidine ammonium salt

Synonyme(s) :

GpC

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About This Item

Formule linéaire :
C19H25N8O12P · NH3
Numéro CAS:
98046-67-4
Poids moléculaire :
605.45
Numéro MDL:
MFCD00058649
Code UNSPSC :
41106305
ID de substance PubChem :
24895064

Forme

solid

Température de stockage

−20°C

Chaîne SMILES 

N.NC1=NC(=O)c2ncn(C3OC(CO)C(OP(O)(=O)OCC4OC(C(O)C4O)N5C=CC(N)=NC5=O)C3O)c2N1

InChI

1S/C19H25N8O12P.H3N/c20-8-1-2-26(19(33)23-8)16-11(30)10(29)7(38-16)4-36-40(34,35)39-13-6(3-28)37-17(12(13)31)27-5-22-9-14(27)24-18(21)25-15(9)32;/h1-2,5-7,10-13,16-17,28-31H,3-4H2,(H,34,35)(H2,20,23,33)(H3,21,24,25,32);1H3

Clé InChI

PPSONIOCBRREER-UHFFFAOYSA-N

Application

Guanylyl(3′5′)cytidine is an oligonucleotide pyrimidine dimer used as a substrate to study the specificity and kinetics of various RNases such as RNase T1 and its mutations.

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
012H7832

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Holger Kruse et al.
Journal of chemical theory and computation, 15(1), 95-115 (2018-11-30)
The stacking energies of 10 unique B-DNA base-pair steps were calculated with highly accurate quantum chemistry and used as reference values in a thorough benchmark of (dispersion-corrected) DFT, wave function methods, tight-binding methods, and different force fields, including charge variants
Min Ju Park et al.
Journal of microbiological methods, 159, 112-119 (2018-12-12)
Bifidobacteria are representative probiotics which are defined as live microorganisms that confer a health benefit on the host. Because of their safety and healthfulness when applied to humans, bifidobacteria are suitable as genetically engineered bacteria for applications to benefit human
E Kathleen Carter et al.
Physical chemistry chemical physics : PCCP, 21(4), 1841-1851 (2019-01-11)
Regulation of gene-expression by specific targeting of protein-nucleic acid interactions has been a long-standing goal in medicinal chemistry. Transcription factors are considered "undruggable" because they lack binding sites well suited for binding small-molecules. In order to overcome this obstacle, we
Snawar Hussain et al.
Acta tropica, 173, 136-146 (2017-06-14)
Zika virus is a zoonotic pathogen, which have made frequent incursion into the human population in Africa and South East Asia over the course of several decades but never reached to the pandemic proportions until the most recent outbreak. Viruses
Elena Loreti et al.
Plant physiology, 182(1), 287-300 (2019-07-31)
In plants, hypoxia can be induced by submergence, and the lack of oxygen impairs mitochondrial respiration, thus affecting the plant's energy status. Hypoxia has major effects on gene expression; these changes induce key responses that help meet the needs of
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