F8055
FGR, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonyme(s) :
SRC2, c-fgr, p55c-fgr
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About This Item
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.32
Produits recommandés
Produit recombinant
expressed in baculovirus infected Sf9 cells
Niveau de qualité
Gamme de produits
PRECISIO® Kinase
Pureté
≥70% (SDS-PAGE)
Forme
buffered aqueous glycerol solution
Activité spécifique
242-328 nmol/min·mg
Poids mol.
~86 kDa
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−70°C
Informations sur le gène
human ... FGR(2268)
Description générale
Src family of tyrosine kinases is grouped into two classes- those with wide range of expression, and those with narrow range of tissue expression. Fgr belongs to the latter group. This protein has six functional domains namely, Src homology domain 4 (SH4), a unique domain, SH3 domain, SH2 domain, the catalytic SH1 domain, and a regulatory region in C-terminal. It is expressed in natural killer cells, monocytes and granulocytes.
Actions biochimiques/physiologiques
FGR interacts with Fc?RII and thus, regulates Fc?RII-mediated signaling cascade.
This protein is expressed in B-cells of patients with Epstein-Barr virus-associated lymphoproliferative disease and chronic lymphocytic leukemia. It is also expressed in normal mantle zone B-cells and is controlled developmentally during the differentiation of myelomonocytes.
This protein is expressed in B-cells of patients with Epstein-Barr virus-associated lymphoproliferative disease and chronic lymphocytic leukemia. It is also expressed in normal mantle zone B-cells and is controlled developmentally during the differentiation of myelomonocytes.
Forme physique
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Informations légales
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificats d'analyse (COA)
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C L Willman et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(13), 4480-4484 (1987-07-01)
To study the expression of src-related protooncogenes during the development of myeloid cells and the regulation of these genes by the colony-stimulating factors that control myelopoiesis, normal monocytic cells at distinct stages of differentiation were derived from murine bone marrow
F Hamada et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(13), 6305-6309 (1993-07-01)
The interaction of Fc receptors with antibody-antigen complexes activates multiple biological functions in hematopoietic cells. Recently, protein-tyrosine phosphorylation has been suggested to be involved in Fc receptor-mediated cell signaling. Here we show that the Src-like protein-tyrosine kinase Fgr, which is
M S Cheah et al.
Nature, 319(6050), 238-240 (1986-01-16)
Several acute transforming retroviruses encode tyrosine-specific protein kinases which possess structural and functional relationships to cell-surface receptors for certain growth factors. One such tyrosine kinase is encoded by the onc gene, v-fgr, of Gardner-Rasheed feline sarcoma virus (GR-FeSV). Recently, we
D C Link et al.
Blood, 85(2), 472-479 (1995-01-15)
The proto-oncogene c-fgr is a member of the c-src gene family of cytoplasmic tyrosine kinases. Previous studies have suggested that it is normally expressed in neutrophils, monocytes, macrophages, and natural killer cells. c-fgr is also expressed in the B cells
A G Tatosyan et al.
Biochemistry. Biokhimiia, 65(1), 49-58 (2000-03-07)
Tyrosine kinases of the Src family are involved in different signal transduction pathways in cells. The corresponding genes participate in such vital processes as growth, differentiation, adhesion, transcription, etc. Specific structural changes confer oncogenic properties to the Src protein. In
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