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F7807

Sigma-Aldrich

Prostaglandin F Synthase human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonyme(s) :

17-beta-hydroxysteroid dehydrogenase type 5, AKR1C3, aldo-keto reductase family 1 member C3, indanol dehydrogenase

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About This Item

Numéro CAS:
55976-95-9
Numéro de classification (Commission des enzymes):
1.1.1.188 (BRENDA, IUBMB)
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.54

Produit recombinant

expressed in E. coli

Niveau de qualité

200

Description

contains a C-terminal hexahistidine tag

Pureté

≥90% (SDS-PAGE)

Forme

liquid

Activité spécifique

≥0.4 μmol/mg protein

Poids mol.

~37 kDa

Numéro d'accès NCBI

NP_003730

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... AKR1C3(8644)

Application

Prostaglandin F synthase (PGF synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. Prostaglandin F synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. PGF synthase is also used to study kidney and renal cell carcinoma .

Actions biochimiques/physiologiques

PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosterone, estrone to 17β-estradiol, prostaglandin H2 to PGF2α, and PGD2 to 9α,11β-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways .

Définition de l'unité

One unit is defined as the amount of enzyme required to produce 1 μmol of NADP per minute at 37°C in 50 mM KPO4 pH 7.2 containing 250 μM NADPH and 25 μM 9,10-phenanthrenequinone

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Trevor M Penning et al.
Annals of the New York Academy of Sciences, 1155, 33-42 (2009-03-03)
Prostate and breast cancer are hormone-dependent malignancies of the aging male and female and require the local production of androgens and estrogens to stimulate cell proliferation. Aldo-keto reductases (AKR) play key roles in this process. In the prostate, AKR1C3 (type
[Prostaglandin synthases with thioredoxin domain].
Kikuko Watanabe
Seikagaku. The Journal of Japanese Biochemical Society, 82(11), 1041-1046 (2011-01-14)
Agnieszka Waclawik et al.
Reproduction (Cambridge, England), 140(4), 613-622 (2010-07-10)
Oxytocin (OXT) and tumor necrosis factor α (TNF) have been implicated in the control of luteolysis by stimulating endometrial secretion of luteolytic prostaglandin F(2α) (PGF(2α)). Nevertheless, OXT concentration in porcine uterine lumen increases markedly on days 11-12 of pregnancy, and
R J Phillips et al.
Molecular human reproduction, 17(1), 1-13 (2010-07-03)
Prostaglandins (PGs) are important factors in the physiology of human parturition and the control of uterine contractility. We have characterized the expression of 15 genes from all stages of the PG pathway in human pregnant and non-pregnant (NP) myometrium and
Keishi Yamaguchi et al.
Journal of synchrotron radiation, 18(1), 66-69 (2010-12-21)
Old yellow enzyme (OYE) is an NADPH oxidoreductase which contains flavin mononucleotide as prosthetic group. The X-ray structures of OYE from Trypanosoma cruzi (TcOYE) which produces prostaglandin (PG) F(2α) from PGH(2) have been determined in the presence or absence of
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