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F6926

Sigma-Aldrich

Fibroblast Growth Factor-8b from mouse

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonyme(s) :

FGF-8b

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About This Item

Numéro MDL:
MFCD01323276
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

mouse

Niveau de qualité

100

Produit recombinant

expressed in E. coli

Pureté

>97% (SDS-PAGE)

Forme

lyophilized powder

Puissance

15-60 ng/mL

Poids mol.

calculated mol wt 23.6 kDa
predicted mol wt 22 kDa

Conditionnement

pkg of 25 μg

Conditions de stockage

avoid repeated freeze/thaw cycles

Impuretés

endotoxin, tested

Numéro d'accès UniProt

P37237

Température de stockage

−20°C

Informations sur le gène

mouse ... Fgf8(14179)

Description générale

Fibroblast growth factor 8 (FGF8) is a member of the FGF family, and was initially cloned from androgen-dependent mouse mammary carcinoma cell line. Alternative splicing of this gene produces four different isoforms mainly, FGF8a, FGF8b, FGF8e and FGF8f.

Application

Fibroblast Growth Factor-8b from mouse has been used-
  • for subgerminal cavity injection in fertilized quail, chicken, turtle and emu eggs
  • in the induction of neural differentiation in stem cells from Human Exfoliated Deciduous teeth (SHED) and
  • in experiments conducted on fertilized hens′ eggs, where FGF8 induced SOX3 gene.

Actions biochimiques/physiologiques

FGF-8b is involved in ectodermal differentiation in the post-gastrulation embryo, including outgrowth and patterning of the face, limbs, and central nervous system. FGF-8b activates the "c" splice form of FGFR-2, FGFR-3, and FGFR-4.
Fibroblast growth factor 8b (FGF8b) isoform of FGF8 has the most potent angiogenic and tumorigenic properties. In prostate cancer, it is responsible for angiogenesis, tumorigenesis and invasion. Exogenous expression of this gene in prostate epithelium leads to prostatic intraepithelial neoplasia (PIN). It also interacts with pattern recognition receptor long pentraxin-3 (PTX3), which is involved in local inflammation.

Forme physique

Lyophilized from a 0.2μm filtered solution in 20mM MOPS, 0.1M sodium sulfate, 0.02% Brij-35, pH 7 containing 50ug of BSA per 1μg as a carrier protein

Remarque sur l'analyse

The biological activity is measured by its ability to stimulate proliferation of NR6R-3T3 fibroblasts.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319

Conseils de prudence

P305 + P351 + P338

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Claudia Linker et al.
Development (Cambridge, England), 131(22), 5671-5681 (2004-10-29)
A dominant molecular explanation for neural induction is the 'default model', which proposes that the ectoderm is pre-programmed towards a neural fate, but is normally inhibited by endogenous BMPs. Although there is strong evidence favouring this in Xenopus, data from
Hyung Chul Lee et al.
Development genes and evolution, 232(5-6), 115-123 (2022-09-24)
During primitive streak formation in the chick embryo, cells undergo mesendoderm specification and convergent extension at the same time and in the same cells. Previous work has implicated cVG1 (GDF3) as a key factor for induction of primitive streak identity
Cantas Alev et al.
Development (Cambridge, England), 140(13), 2691-2696 (2013-05-24)
Mesoderm is formed during gastrulation. This process takes place at the blastopore in lower vertebrates and in the primitive streak (streak) in amniotes. The evolutionary relationship between the blastopore and the streak is unresolved, and the morphogenetic and molecular changes
Abolghasem Esmaeili et al.
Avicenna journal of medical biotechnology, 6(1), 21-26 (2014-02-20)
Stem cells from Human Exfoliated Deciduous teeth (SHED) have the capability to differentiate into neural cells. Neurotrophins including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) have neurogenesis, neurotrophic, or neuroprotective effects and are expressed
Arianna Giacomini et al.
Oncotarget, 6(15), 13790-13802 (2015-04-29)
Fibroblast growth factor-8b (FGF8b) affects the epithelial/stromal compartments of steroid hormone-regulated tumors by exerting an autocrine activity on cancer cells and a paracrine pro-angiogenic function, thus contributing to tumor progression. The FGF8b/FGF receptor (FGFR) system may therefore represent a target

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