F4381

Furosemide

≥98% (HPLC), powder, NKCC symporter inhibitor

• Synonyme(s) : 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid, 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
• Formule empirique (notation de Hill): C₁₂H₁₁ClN₂O₅S
• Numéro CAS: 54-31-9
• Poids moléculaire : 330.74
• Numéro CE : 200-203-6
• Numéro MDL: MFCD00010549
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277714
• Nomenclature NACRES : NA.77

Propriétés

• product name: Furosemide,
• Source biologique: synthetic (organic)
• Pureté: ≥98% (HPLC)
• Forme: powder
• Pf: 220 °C (dec.) (lit.)
• Solubilité: acetone: 50 mg/mL, clear to slightly hazy, colorless to yellow
• Auteur: Sanofi Aventis
• Température de stockage: room temp
• Chaîne SMILES: NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
• InChI: 1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
• Clé InChI: ZZUFCTLCJUWOSV-UHFFFAOYSA-N
• Informations sur le gène: human ... ALB(213) , CYP1A2(1544) , SLC12A1(6557)

Description

Description générale

Furosemide is a an ototoxic high-ceiling diuretic.

Application

Furosemide has been used:

• to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
• to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
• as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)

Actions biochimiques/physiologiques

"High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.

Furosemide can block the Na⁺/K⁺/2Cl^- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure.

Inhibits ion co-transport in the kidney.

Caractéristiques et avantages

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This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H360FD
• Conseils de prudence: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Classification des risques: Acute Tox. 4 Oral - Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges