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F3393

Sigma-Aldrich

Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit

fractionated antiserum, lyophilized powder

Synonyme(s) :

Anti-FGF2, Anti-bFGF

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About This Item

Numéro MDL:
MFCD01322020
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

fractionated antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

human, bovine, rat

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1:1,000

Impuretés

endotoxin, tested

Numéro d'accès UniProt

P09038

Application(s)

research pathology

Température de stockage

2-8°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

bovine ... FGF2(281161)
human ... FGF2(2247)
rat ... Fgf2(54250)

Description générale

Fibroblast growth factor-basic (FGFb), also known as NUDT6 (nudix (nucleoside diphosphate linked moiety X)-type motif 6) is encoded by the gene mapped to human chromosome 4q28.1. The FGFb gene spanning 34271 bp on genomic DNA contains 16 exons and six introns. FGFb RNA transcripts are expressed in various human tissues including liver, thymus, spleen, peripheral blood leukocytes, heart skeletal muscle, testis, colon and kidney.

Immunogène

synthetic peptide sequence corresponding to bovine FGF2 (1-24).

Application

Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit has been used in:
  • immunohistochemistry
  • immunostaining
  • immunoblotting

Actions biochimiques/physiologiques

Fibroblast Growth Factor Basic (also known as bFGF) is a pleotropic cytokine that that is a potent mitogenic factor. On binding to its cognate receptor tyrosine kinase, FGFR, bFGF is capable of activation of pathways such as MAPK and PI3K and produce cellular effects in varied cell types. Fibroblast Growth Factor-basic is reported to induce proliferation of fibroblasts, differentiation, wound healing and regeneration, limb formation, tissue remodeling and angiogenesis.

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Remarque sur l'analyse

Bioactivity: Anti-Fibroblast Growth Factor-Basic (1-24) caused a dose-dependent decrease in the mitogenic activity of FGF-Basic such that a final dilution of 1:50 neutralized the bioactivity of 1 unit of FGF Basic.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

B G Condron
Neuron, 24(3), 531-540 (1999-12-14)
In the grasshopper CNS, serotonergic growth cones cross the midline early in development and initiate expression of serotonin uptake activity, or SERT. To test if the midline contains an activity that induces SERT, cuts were made that separated serotonergic cell
Effect of human umbilical cord blood mesenchymal stem cells administered by intravenous or intravitreal routes on cryo-induced retinal injury
Mohamed EM, et al.
IUBMB Life, 69(3), 188-201 (2017)
Correlation of astrocyte elevated gene-1, basic-fibroblast growth factor, beta-catenin, Ki-67, tumor necrosis factor-alfa with prognostic parameters in ductal carcinomas and ductal intraepithelial neoplasms
Erdem H, et al.
Nigerian Journal of Clinical Practice, 18(5), 638-643 (2015)
Natale Belluardo et al.
Brain research, 1193, 12-24 (2008-01-15)
Precursor cell proliferation is present in the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the dentate gyrus of the hippocampus of adult rat and persists during aging although at reduced levels. Previous studies have
Joost F M Lensen et al.
Journal of the American Society of Nephrology : JASN, 16(5), 1279-1288 (2005-03-25)
Glycosaminoglycans (GAG) play an important role in renal homeostasis. They are strongly negatively charged polysaccharides that bind and modulate a myriad of proteins, including growth factors, cytokines, and enzymes. With the aid of specific phage display-derived antibodies, the distribution of
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