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F0805

Sigma-Aldrich

Anti-FOXL2 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-Forkhead L2, Anti-Forkhead Transcription Factor

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About This Item

Numéro MDL:
MFCD09039192
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

mouse, hamster

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 0.2 μg/mL using murine prenatal folicle
indirect immunofluorescence: 2 μg/mL using KK1 granulosa cells
western blot: 0.2 μg/mL using CHO whole cell lysate

Numéro d'accès UniProt

O88470

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Foxl2(26927)

Immunogène

synthetic peptide M(1)MASYPEPEDTAGT(14) corresponding to amino acid residues 1-14 from mouse FOXL2. This sequence is completely conserved in mouse and rat and 92% conserved in human.

Application

Anti-FOXL2 antibody produced in rabbit is suitable for the following applications:
  • Immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 0.2μg/mL using murine prenatal folicle
  • Indirect immunofluorescence at a concentration of 2μg/mL using KK1 granulosa cells
  • Western blotting (at a concentration of 0.2μg/mL using CHO whole cell lysate) or immunoblot analysis.

Actions biochimiques/physiologiques

Forkhead box protein L2 is a protein encoded by the FOXL2 gene in humans. The gene FOXL2 encodes a member of the fork-head-winged-helix family of transcription factors. It is expressed early during female gonadal development and is expressed in normal ovarian stroma and ovarian neoplasms with granulosa cell lineage. FOXL gene encodes an essential transcription factor in the ovary and helps in female sex determination, follicle recruitment and granulosa cell development. Its mutation is specific to AGCTs in the ovary and is useful for diagnosis of disease. FOXL2 acts as an oncogene or tumour suppressor depending on the genetic context that is the GCT subtype.

Description de la cible

FOXL2 encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3.

Forme physique

Provided as 100 μg of affinity purified IgG (1 mg/mL) in phosphate buffered saline containing 1 mg/mL bovine serum albumin and 0.05% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Fubiao Shi et al.
Human molecular genetics, 23(14), 3792-3800 (2014-02-26)
Blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) is an autosomal dominant genetic disorder characterized by small palpebral fissures and other craniofacial malformations, often with (type I) but could also without (type II) premature ovarian failure. While mutations of the forkhead transcription
Maria Westerhoff et al.
Human pathology, 45(5), 1010-1014 (2014-04-22)
FOXL2, a gene encoding a member of the fork-head-winged-helix family of transcription factors, is one of the earliest expressed genes during female gonadal development. It is expressed in normal ovarian stroma and ovarian neoplasms with granulosa cell lineage. Nonovarian tumors
Roseanne Rosario et al.
Gynecologic oncology, 133(2), 382-387 (2013-12-18)
It has been four years since the discovery of the FOXL2 402C>G mutation in adult ovarian granulosa cell tumours. Yet to date, there have been few studies which have investigated the precise role of the mutation in tumour pathogenesis. This
Akimasa Takahashi et al.
The Tohoku journal of experimental medicine, 231(4), 243-250 (2013-11-22)
Adult-type granulosa cell tumor (AGCT) is a rare class of malignant ovarian tumor with unique features, characterized by slow growth, late recurrence, relatively good prognosis and unified cause in almost all patients. The forkhead box L2 (FOXL2) gene encodes an
Stella Tran et al.
Molecular endocrinology (Baltimore, Md.), 27(3), 407-421 (2013-01-24)
Impairments in pituitary FSH synthesis or action cause infertility. However, causes of FSH dysregulation are poorly described, in part because of our incomplete understanding of mechanisms controlling FSH synthesis. Previously, we discovered a critical role for forkhead protein L2 (FOXL2)
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