Accéder au contenu
MilliporeSigma
Toutes les photos(1)

Key Documents

E1378

Sigma-Aldrich

Escin

≥95%, powder

Synonyme(s) :

Aescin

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Numéro CAS:
6805-41-0
Numéro CE :
229-880-6
Numéro MDL:
MFCD00076054
Code UNSPSC :
12352201
ID de substance PubChem :
24894403
Nomenclature NACRES :
NA.25

Source biologique

plant (Aesculus chinensis)

Niveau de qualité

200

Pureté

≥95%

Forme

powder

Impuretés

≤6.0% Water (Karl Fischer)

Couleur

white

Solubilité

methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

Chaîne SMILES 

C\C=C(/C)C(=O)OC1[C@H](OC(C)=O)C2(CO)[C@H](O)C[C@]3(C)C(=CCC4C5(C)CCC(O[C@@H]6O[C@@H]([C@@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O[C@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)C(O)=O)[C@](C)(CO)C5CCC34C)C2CC1(C)C

InChI

1S/C55H86O24/c1-10-23(2)46(71)79-43-44(72-24(3)60)55(22-59)26(17-50(43,4)5)25-11-12-30-51(6)15-14-32(52(7,21-58)29(51)13-16-53(30,8)54(25,9)18-31(55)61)75-49-41(77-48-38(67)36(65)34(63)28(20-57)74-48)39(68)40(42(78-49)45(69)70)76-47-37(66)35(64)33(62)27(19-56)73-47/h10-11,26-44,47-49,56-59,61-68H,12-22H2,1-9H3,(H,69,70)/b23-10+/t26?,27-,28-,29?,30?,31-,32?,33-,34-,35+,36+,37-,38-,39+,40+,41-,42+,43?,44+,47+,48-,49-,51?,52-,53?,54-,55?/m1/s1

Clé InChI

AXNVHPCVMSNXNP-YSYFQUGBSA-N

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Application

Escin, a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, is used and studied as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent. It may be used to study its pharmacokinetics, safety and efficacy as a chemosensitizer and modulator of NF-κ B cell signaling.

Autres remarques

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302 + H332

Classification des risques

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 8

1 of 8

Sigma-Aldrich

Sigma-Aldrich

5.30918

PTC-124

AMMONIUM GLYCYRRHIZINATE AldrichCPR

S641529

AMMONIUM GLYCYRRHIZINATE

Arbutin ≥98% (HPLC)

Sigma-Aldrich

A4256

Arbutin

α-Hederin primary reference standard

01240585

α-Hederin

1,4-Cineole analytical standard

Supelco

27393

1,4-Cineole

Esculin European Pharmacopoeia (EP) Reference Standard

Y0001612

Esculin

Soyasaponine I

Sigma-Aldrich

S9951

Soyasaponine I

Hederacoside C primary reference standard

00930585

Hederacoside C

Wenyu Xin et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 18(4), 272-277 (2010-09-21)
Escin, a natural mixture of triterpenoid saponins isolated from the seed of the horse chestnut (Aesculus hippocastanum), had been demonstrated to possess anti-edematous and anti-inflammatory effects. The present study was designed to investigate whether escin exhibits synergistic anti-inflammatory effects when
Xiu-Jun Wu et al.
Journal of ethnopharmacology, 151(2), 839-845 (2013-12-18)
Adequate pharmacokinetic data of escin, a natural mixture of triterpene saponins used for the treatment of chronic venous insufficiency, hemorrhoids, inflammation and edema, is of special interest in view of the growing use of escin agent in clinical medicine. However
Zhenzhen Zhang et al.
Phytotherapy research : PTR, 25(12), 1747-1755 (2011-04-01)
Escin sodium has been used in the clinic as an antioedematous, antiexudative and vasoprotective agent for many years and has shown excellent tolerability. However, little is known about its anticancer activity. This is a report for the first time that
Kuzhuvelil B Harikumar et al.
Molecular pharmacology, 77(5), 818-827 (2010-01-28)
Agents that can enhance tumor cell apoptosis and inhibit invasion have potential for the treatment of cancer. Here, we report the identification of escin, a pentacyclic triterpenoid from horse chestnut that exhibits antitumor potential against leukemia and multiple myeloma. Whether
R W Frick
Angiology, 51(3), 197-205 (2000-04-01)
Escin, hydroxyethylrutoside (HR), and Daflon have been shown to be safe and effective for the treatment of chronic venous insufficiency (CVI). They seem to work differently than compression therapy, suggesting that they would usefully augment this therapy. All three phlebotonics
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique