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D5318

DCP-LA

Name: DCP-LA
Brand: SIGMA

≥95% (HPLC), oil

Synonyme(s) :

2-[(2-pentylcyclopropyl)methyl]cyclopropaneoctanoic acid, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid, FR 236924

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About This Item

Formule empirique (notation de Hill):

C₂₀H₃₆O₂

Numéro CAS:

28399-31-7

Poids moléculaire :

308.50

Numéro MDL:

MFCD09265251

Code UNSPSC :

12352200

ID de substance PubChem :

24724463

Nomenclature NACRES :

NA.77

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Sigma-Aldrich

128708

Ferulic acid

Niveau de qualité

100

Pureté

≥95% (HPLC)

Forme

oil

Couleur

clear

Solubilité

DMSO: >2 mg/mL

Température de stockage

2-8°C

Chaîne SMILES

CCCCCC1CC1CC2CC2CCCCCCCC(O)=O

InChI

1S/C20H36O2/c1-2-3-7-10-16-13-18(16)15-19-14-17(19)11-8-5-4-6-9-12-20(21)22/h16-19H,2-15H2,1H3,(H,21,22)

Clé InChI

CONYTTFKIUJZOF-UHFFFAOYSA-N

Actions biochimiques/physiologiques

DCP-LA is a selective PKC-epsilon (PKC-ε) activator. In the in situ PKC assay with a reversed phase high-performance liquid chromatography, DCP-LA significantly activated PKC in PC-12 cells in a concentration (10 nM-100 μM)-dependent manner, with the maximal effect at 100 nM. DCP-LA has over a 7-fold greater potency for activation of PKC-ε over other PKC isozymes.

Caractéristiques et avantages

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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The linoleic acid derivative DCP-LA selectively activates PKC-epsilon, possibly binding to the phosphatidylserine binding site.

Takeshi Kanno et al.

Journal of lipid research, 47(6), 1146-1156 (2006-03-08)

This study examined the effect of 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA), a newly synthesized linoleic acid derivative with cyclopropane rings instead of cis-double bonds, on protein kinase C (PKC) activity. In the in situ PKC assay with reverse-phase high-performance liquid chromatography, DCP-LA

Linoleic acid derivative DCP-LA improves learning impairment in SAMP8.

Takahiro Yaguchi et al.

Neuroreport, 17(1), 105-108 (2005-12-20)

In the water-maze test, the linoleic acid derivative, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) (1 mg/kg, intraperitoneally), significantly shortened the prolonged latency for accelerated-senescence-prone mice 8 (SAMP8), reaching a level similar to the latency for accelerated-senescence-resistant mice 1 (SAMR1) as control. In the

Sasanquasaponin induces increase of Cl‑/HCO3‑ exchange of anion exchanger 3 and promotes intracellular Cl‑ efflux in hypoxia/reoxygenation cardiomyocytes.

Ling-Yu Qiu et al.

Molecular medicine reports, 16(3), 2953-2961 (2017-07-06)

Anion exchanger 3 (AE3) is known to serve crucial roles in maintaining intracellular chloride homeostasis by facilitating the reversible electroneutral exchange of Cl‑ for HCO3‑ across the plasma membrane. Our previous studies reported that sasanquasaponin (SQS) can inhibit hypoxia/reoxygenation (H/R)‑induced

Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway.

Joshua H K Tam et al.

PloS one, 11(10), e0161445-e0161445 (2016-10-25)

The amyloid hypothesis posits that the production of β-amyloid (Aβ) aggregates leads to neurodegeneration and cognitive decline associated with AD. Aβ is produced by sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretase. While nascent APP is

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