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C7736

Sigma-Aldrich

Anti-Centrin antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-CEN1, Anti-CETN

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About This Item

Numéro MDL:
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Le tarif et la disponibilité ne sont pas disponibles actuellement.

Source biologique

rabbit

Niveau de qualité

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 21 kDa

Espèces réactives

human

Technique(s)

microarray: suitable
western blot: 1:2,000 using 293-T exp.Hu.Centrin-1LY117608 or 293-T exp.Hu.Centrin1-FLAG LY401316

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Cet article
HPA036722SAB5700653SAB5701155
conjugate

unconjugated

conjugate

unconjugated

conjugate

-

conjugate

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

-

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

-

product line

-

Gene Information

human ... CD34(947)

Gene Information

human ... CD34(947)

Gene Information

human ... CD34(947)

Gene Information

human ... CD34(947)

Description générale

Centrins are acidic proteins, that are usually found in all eukaryotes. Centrin 1 (CETN1), an intron-less gene is mapped on human chromosome 18p11. It possesses certain features of an expressed retroposon.
The centrosome, the major microtubule-organizing center (MTOC) in the animal cell, is a key determinant in the organization of the cytoplasm, in the determination of cell polarity, and in the establishment of mitotic spindle poles during the cell cycle. Centrin is a member of the calcium binding E-F hand protein superfamily present in the centrosome pericentriolar matrix.
Three separate centrin genes have been identified in human cells: centrin 1, 2, and 3. Centrin 1 shows strong amino acid homology to centrin 2 (85%), but lower homology to centrin 3 (54%) and CDC31 (50%) from the yeast S. cerevisiae. Centrin has a fundamental role in the MTOC structure and function. Phenotypic analysis of mutants in Chlamydomonas caltractin and the yeast CDC31 genes have indicated that the protein is required for proper duplication and segregation of the MTOC in the respective cells.

Immunogène

synthetic peptide corresponding to the C-terminus of human centrin 1 (amino acids 157-172). The sequence is highly conserved in centrin 1 of many species, e.g. mouse, Drosophila, and Xenopus. It is also found in human and mouse centrin 2, but is not found in centrin 3.

Application

Anti-Centrin antibody produced in rabbit has been used in:
  • immunofluorescence
  • immunoblotting
  • immunofluorescence microscopy

Actions biochimiques/physiologiques

Centrin has a fundamental role in the microtubule-organizing center (MTOC) structure and function. These proteins has imperative roles in centrosome positioning and segregation. Centrin also participates in cytokinesis and cell cycle progression.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Consulter la Bibliothèque de documents

Asterless is a scaffold for the onset of centriole assembly
Dzhindzhev NS, et al.
Nature, 467(7316), 714-718 (2010)
DNA Damage-Induced Accumulation of Centrosomal Chk1 Contributes to its Checkpoint Function
Looffler H, et al.
Cell Cycle, 6(20), 2541-2548 (2007)
CETN1 is a cancer testis antigen with expression in prostate and pancreatic cancers
Kim JJ, et al.
Biomarker research, 1, 22-22 (2013)
M E Lachowicz-Scroggins et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 47(12), 1534-1545 (2017-08-24)
Bronchial epithelial goblet cell metaplasia (GCM) with hyperplasia is a prominent feature of asthma, but the effects of treatment with corticosteroids alone or in combination with a long-acting β To determine whether corticosteroid alone or in combination with a LABA
Optimization of purification method and characterization of recombinant human Centrin-1
Phanindranath R, et al.
Protein Expression and Purification, 124, 48-54 (2016)

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