C1603
Anti-Calcium Channel (α1C Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
Anti-CACH2, Anti-CACN2, Anti-CACNL1A1, Anti-CCHL1A1, Anti-CaV1.2, Anti-LQT8, Anti-TS, Anti-TS. LQT8
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About This Item
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Espèces réactives
human, rat, mouse, rabbit
Technique(s)
immunohistochemistry: suitable using Rat brain sections
western blot: 1:200 using Rat brain and rat heart membranes
Numéro d'accès UniProt
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
mouse ... Cacna1c(12288)
Description générale
L-type of Voltage-gated Ca2+ Channels (L-type VGCC) is a high voltage-activated channel that exerts spatial and temporal control over cellular calcium concentrations and modulates function such as neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression and neuronal survival. Calcium dependent processes are important in synaptic modification and thus alterations in calcium channel function may be important for both modifying synaptic plasticity and also in age-related neurodegenerative diseases. Calcium channel antagonists are used as antiarrhythmics and in the treatment of hypertension and may even be neuroprotective in Parkinson′s Disease. Calcium Channel α1C subunit is a pore-forming subunit that together with β subunits generates the necessary signal for membrane targeting of class C L-type calcium channels.
Spécificité
Anti-Voltage-gated Calcium Channel α1C subunit recognizes the α1C subunit by immunoblotting in rat brain and rat heart membranes. Reactivity has been confirmed for rat, mouse, rabbit and human.
Immunogène
synthetic peptide corresponding to amino acids 848 to 865 of rat α1C.
Application
Anti-Calcium Channel (α1C Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit has been used in:
- SDS-PAGE
- western blotting
- coimmunoprecipitation
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
Rabbit polyclonal anti-Calcium Channel α1C subunit antibody is used to tag class C L-type calcium channel subunit α1C for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as ELISA, immunoblotting, and immunoprecipitation. It is used as a probe to determine the presence and roles of calcium channel subunit α1C in class C L-type voltage-gated Ca2+ channel subunit complexes.
Forme physique
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Réf. du produit
Description
Tarif
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Kato HK, et al.
The Journal of Physiology, 590(13), 3019-3034 (2012)
A S Axelsson et al.
Nature communications, 8, 15652-15652 (2017-06-07)
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Calcium channel function and regulation in beta1-and beta2-adrenoceptor transgenic mice
Foerster K, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 369(5), 490-495 (2004)
Nina Daschil et al.
Pharmacology, 93(1-2), 24-31 (2014-01-18)
It is well established that reactive astrocytes express L-type calcium channels (LTCC), but their functional role is completely unknown. We have recently shown that reactive astrocytes highly express the CaV1.2 α1-subunit around β-amyloid (Aβ) plaques in an Alzheimer mouse model.
Jing Liu et al.
American journal of physiology. Cell physiology, 297(1), C152-C159 (2009-04-10)
Cardiomyocytes (CMs) are nonregenerative. Self-renewable pluripotent human embryonic stem cells (hESCs) can differentiate into CMs for cell-based therapies. We recently reported that Ca(2+) handling, crucial to excitation-contraction coupling of hESC-derived CMs (hESC-CMs), is functional but immature. Such immature properties as
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