B9031

(−)-Bilobalide from Ginkgo biloba leaves

≥93% (HPLC)

• Synonyme(s) : Bilobalide
• Formule empirique (notation de Hill): C₁₅H₁₈O₈
• Numéro CAS: 33570-04-6
• Poids moléculaire : 326.30
• Numéro MDL: MFCD00238547
• Code UNSPSC : 85151701
• ID de substance PubChem : 24892116

Propriétés

• Source biologique: plant leaves (Ginkgo biloba)
• Niveau de qualité: 100
• Pureté: ≥93% (HPLC)
• Forme: powder
• Technique(s): HPLC: suitable
• Couleur: white
• Température de stockage: −20°C
• Chaîne SMILES: CC(C)(C)[C@]1(O)CC2OC(=O)C[C@@]23C(=O)OC4OC(=O)[C@H](O)[C@]134
• InChI: 1S/C15H18O8/c1-12(2,3)14(20)4-6-13(5-7(16)21-6)10(19)23-11-15(13,14)8(17)9(18)22-11/h6,8,11,17,20H,4-5H2,1-3H3/t6-,8-,11-,13-,14+,15+/m0/s1
• Clé InChI: MOLPUWBMSBJXER-YDGSQGCISA-N

Description

Description générale

Bilobalide is a biologically active terpenic trilactone (terpenoid) extracted from Ginkgo biloba. It is synthesized from geranylgeranyl pyrophosphate (GGPP).

Application

(-)-Bilobalide from Ginkgo biloba leaves has been used as a reference substance to study the antimicrobial activity of different fractions of G.biloba leaves against a number of Gram-positive and negative bacteria and yeasts.

Actions biochimiques/physiologiques

Bilobalide is an inducer of cytochrome P450 enzymes CYP3A1 and CYP1A2. It exhibits neuroprotective, anti-inflammatory, anti-oxidative and anti-apoptotic properties. Bilobalide, a γ-aminobutyric acid (GABA) A_A-rho, 5-hydroxytryptamine type 3 (5-HT(3)) receptor antagonist, may be used to study the function of these receptors in the brain processes such as cognition and memory. It serves as a specific platelet-activating factor receptor antagonist, which helps in the treatment of cardiovascular (Alzheimer′s disease) and cerebrovascular diseases.

Bioactive terpenoid found in Ginkgo biloba.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)