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Principaux documents

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B7559

Sigma-Aldrich

BW A4C

≥98% (HPLC)

Synonyme(s) :

N-[(E)-3-(3-Phenoxyphenyl)prop-2-enyl]acetohydroxamic acid

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About This Item

Formule empirique (notation de Hill):
C17H17NO3
Numéro CAS:
106328-57-8
Poids moléculaire :
283.32
Numéro MDL:
MFCD00869694
Code UNSPSC :
12352202
ID de substance PubChem :
24724425
Nomenclature NACRES :
NA.32

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Conditions de stockage

protect from light

Couleur

white

Pf

79.3-80.1 °C (lit.)

Solubilité

DMSO: 20 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

CC(=O)N(O)C\C=C\c1cccc(Oc2ccccc2)c1

InChI

1S/C17H17NO3/c1-14(19)18(20)12-6-8-15-7-5-11-17(13-15)21-16-9-3-2-4-10-16/h2-11,13,20H,12H2,1H3/b8-6+

Clé InChI

CEUDWZXMLMKPNN-SOFGYWHQSA-N

Informations sur le gène

human ... ALOX5(240)
rat ... Alox5(25290)

Actions biochimiques/physiologiques

Selective 5-lipoxygenase (5-LOX) inhibitor. Inhibits synthesis of LTB4.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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K Nakahama et al.
Prostaglandins, leukotrienes, and essential fatty acids, 51(3), 177-182 (1994-09-01)
The role of endogenously produced arachidonic acid metabolites on glomerulonephritis was investigated using cultured rat mesangial cells. The cultured mesangial cells could produce prostaglandin (PG) E2 and F2 alpha and 12-hydroxyeicosatetraenoic acid (12-HETE). The treatment of the mesangial cells with
C Franchi-Miller et al.
Bone, 17(2), 185-191 (1995-08-01)
The role of leukotrienes on bone resorption was tested in a well-standardized model of bone remodeling by inhibiting their biosynthesis with BWA4C, a specific inhibitor of 5-lipoxygenase. After extraction of their upper molars unilaterally, 30 Wistar rats were divided into
S Gök et al.
General pharmacology, 29(5), 789-792 (1997-11-05)
1. The effects of a lipoxygenase inhibitor, BW A4C, on digoxin-induced arrhythmias and cardiac dynamics (contractile force, perfusion pressure, heart rate) were investigated in Langendorff-perfused isolated guinea-pig hearts. In the control group, arrhythmias were induced by 25 micrograms/ml digoxin at
S A Yasin et al.
Journal of neuroendocrinology, 6(2), 179-184 (1994-04-01)
Interleukin-1 (IL-1) and interleukin-6 (IL-6) have been reported to stimulate the release of corticotrophin-releasing hormone (CRH) in vitro, the response being antagonized by the cyclo-oxygenase inhibitor, indomethacin. The effects of cytokines on the other major ACTH-releasing hormone, vasopressin (AVP), and
I D Brodowsky et al.
European journal of pharmacology, 254(1-2), 43-47 (1994-03-11)
Linoleic acid is converted to 8R-hydroperoxylinoleic acid by the soluble 8R-dioxygenase of the fungus Gaeumannomyces graminis. Effects of different lipoxygenase inhibitors on the 8R-dioxygenase were evaluated. Three hydroxamic acid derivatives were investigated. BW A4C (N-(3-phenoxycinnamyl)acetohydroxamic acid) was the most potent
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