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Key Documents

AV45381

Sigma-Aldrich

Anti-PTPRN antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-FLJ16131, Anti-IA-2, Anti-IA-2/PTP, Anti-IA2, Anti-ICA512, Anti-Protein tyrosine phosphatase, receptor type, N, Anti-R-PTP-N

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

96 kDa

Espèces réactives

mouse, dog, rabbit, human, rat

Concentration

0.5 mg - 1 mg/mL

Technique(s)

western blot: suitable

Numéro d'accès NCBI

NP_002837

Numéro d'accès UniProt

Q16849

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... PTPRN(5798)

Immunogène

Synthetic peptide directed towards the middle region of human PTPRN

Application

Anti-PTPRA (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 0.0625μg/ml.

Actions biochimiques/physiologiques

Protein tyrosine phosphatase, receptor type N (PTPRN) is a member of protein tyrosine phosphatase (PTP) family involved in cell growth, differentiation and mitosis. PTPRN acts as an autoantigen in the sera of insulin-dependent diabetes mellitus patients and is the target of autoimmunity.

Séquence

Synthetic peptide located within the following region: EVQQVPSPVSSEPPKAARPPVTPVLLEKKSPLGQSQPTVAGQPSARPAAE

Forme physique

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

E Bonifacio et al.
Diabetes, 50(11), 2451-2458 (2001-10-27)
Several self-antigens have been reported as targets of the autoimmune response in nonobese diabetic (NOD) mice. The aim of this workshop was to identify autoantibody assays that could provide useful markers of autoimmunity in this animal model for type 1
Huichun Liang et al.
Oncogene, 37(15), 1961-1975 (2018-01-26)
It is well documented that hypoxia activates the hypoxia-inducible factor 1-alpha (HIF1α)/vascular endothelial growth factor A (VEGFA) axis to promote angiogenesis in breast cancer. However, it is unclear how this axis is negatively regulated. In this study, we demonstrated that
Tony Tiganis et al.
The Biochemical journal, 402(1), 1-15 (2007-01-24)
It is now well established that the members of the PTP (protein tyrosine phosphatase) superfamily play critical roles in fundamental biological processes. Although there has been much progress in defining the function of PTPs, the task of identifying substrates for

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