A4941

Activin A human

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture

• Synonyme(s) : Activin A Protein, Growth Factor, Human Growth Factor
• Numéro CE : 201-069-1
• Numéro MDL: MFCD02685750
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.32

Propriétés

• product name: Activin A human, ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture
• Source biologique: human
• Niveau de qualité: 200
• Produit recombinant: expressed in baculovirus infected insect cells
• Pureté: ≥95% (SDS-PAGE)
• Forme: lyophilized powder
• Puissance: 1-10 ng/mL ED₅₀
• Poids mol.: dimer 26 kDa (containing 116 amino acid residues βA subunits)
• Conditionnement: pkg of 10 μg; pkg of 5 μg
• Technique(s): cell culture | mammalian: suitable
• Impuretés: endotoxin, tested
• Numéro d'accès UniProt: P08476
• Température de stockage: −20°C
• Informations sur le gène: human ... INHBA(3624)

Description

Description générale

Activin A gene with two exons is mapped to human chromosome 2q35. Activin A also known as inhibin α-subunit belongs to the TGF-β (transforming growth factor-β) superfamily of proteins and its expression is exclusive to gonads, placenta and adrenal cortex.

Application

Activin A human has been used as a constituent of modified barth′s saline used in in vitro induction of pronephros. It has also been used as a constituent of Roswell Park memorial institute (RPMI) media to induce pancreatic differentiation of multipotent dermal fibroblasts in vitro.

Actions biochimiques/physiologiques

Activins play a vital role in the regulation of hormonogenesis, cellular homeostasis and differentiation programs. Elevated expression of activin A and B leads to the loss of muscle mass. Both activin A and B have a potential to act as a serum markers of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).

Forme physique

Lyophilized from 0.2 μm filtered solution in 10 mM sodium citrate, pH 3.0.

Remarque sur l'analyse

The biological activity is determined by its ability to inhibit the proliferation of mouse MPC-11 cells.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable