A2093

Aspirin

meets USP testing specifications

• Synonyme(s) : Acetylsalicylic acid, 2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Aspirin
• Formule linéaire : 2-(CH₃CO₂)C₆H₄CO₂H
• Numéro CAS: 50-78-2
• Poids moléculaire : 180.16
• Numéro Beilstein : 779271
• Numéro CE : 200-064-1
• Numéro MDL: MFCD00002430
• Code UNSPSC : 12352106
• ID de substance PubChem : 24890623
• Nomenclature NACRES : NA.21

Propriétés

• Agence: USP/NF; meets USP testing specifications
• Niveau de qualité: 200
• Forme: powder or crystals
• Pf: 134-136 °C (lit.)
• Application(s): pharmaceutical (small molecule)
• Chaîne SMILES: CC(=O)Oc1ccccc1C(O)=O
• InChI: 1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
• Clé InChI: BSYNRYMUTXBXSQ-UHFFFAOYSA-N
• Informations sur le gène: human ... ITGA2B(3674) , PTGS1(5742) , PTGS2(5743)

Description

Description générale

Aspirin (acetylsalicylic acid) is a nonsteroidal anti-inflammatory drug. It occurs as white crystalline powder and is derived from salicylic acid.

Application

Aspirin has been used:

• as a stabilizer for blood during 13,14-dihydro-15-keto-prostaglandin F2α (PGFM) measurement
• to evaluate cell viability of BV-2 microglial cell line
• in morphogenesis assay

Actions biochimiques/physiologiques

Aspirin is an analgesic and antipyretic agent used in the treatment of fever and pain as in arthritis. It is also associated with cardiovascular diseases.

Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 482.0 °F
• Point d'éclair (°C): 250 °C
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves