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82934

Sigma-Aldrich

7-Hydroxycitronellal

Odorant used in allergy studies

Synonyme(s) :

7-Hydroxy-3,7-dimethyloctanal, Citronellal hydrate

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About This Item

Formule empirique (notation de Hill):
C10H20O2
Numéro CAS:
107-75-5
Poids moléculaire :
172.26
Numéro CE :
203-518-7
Numéro MDL:
MFCD00014681
Code UNSPSC :
12352200
ID de substance PubChem :
57652938
Nomenclature NACRES :
NA.52

Qualité

for molecular biology

Pureté

≥95.0% (GC)

Forme

powder

Densité

0.92 g/mL at 20 °C (lit.)

Température de stockage

room temp

Chaîne SMILES 

[H]C(CC(C)CCCC(O)(C)C)=O

InChI

1S/C10H20O2/c1-9(6-8-11)5-4-7-10(2,3)12/h8-9,12H,4-7H2,1-3H3

Clé InChI

WPFVBOQKRVRMJB-UHFFFAOYSA-N

Description générale

7-Hydroxycitronellal is fragrant sensitizer added frequently to deodorants and perfumes. It is one of the allergens responsible for axillary dermatitis.

Application

Suitable for
  • contact sensitization studies to identify allergens present in cosmetic preparations
  • elucidation of molecular pathways related to allergic reactions
  • analytical standard

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H317,H319

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Consulter la Bibliothèque de documents

Nadège Ade et al.
Toxicological sciences : an official journal of the Society of Toxicology, 107(2), 451-460 (2008-11-27)
Electrophilicity is one of the most common features of skin contact sensitizers and is necessary for protein haptenation. The Keap1 (Kelch-like ECH-associated protein 1)/Nrf2 -signaling pathway is dedicated to the detection of electrophilic stress in cells leading to the upregulation
Clarissa D Villarama et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 42(11), 1719-1725 (2004-09-08)
The clinical relevance of patch test reactions is often difficult to determine. Use tests have been developed to further evaluate the significance of patch test results. We review studies that have defined correlations between the threshold concentrations at patch testing
S Heydorn et al.
Contact dermatitis, 48(6), 324-330 (2003-10-09)
Recently, we showed that 10 x 2% of consecutively patch-tested hand eczema patients had a positive patch test to a selection of fragrances containing fragrances relevant to hand exposure. In this study, we used repeated skin exposure to a patch
Susan P Felter et al.
Regulatory toxicology and pharmacology : RTP, 37(1), 1-10 (2003-03-29)
The National Academy of Science (NAS) risk assessment paradigm has been widely accepted as a framework for estimating risk from exposure to environmental chemicals (NAS, 1983). Within this framework, quantitative risk assessments (QRAs) serve as the cornerstone of health-based exposure
M Krasteva et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 26(5), 563-570 (1996-05-01)
The need to develop predictive tests which could identify potential allergens has been recognized for many years. There is as yet no accepted in vitro method for the assessment of contact sensitizers. We have tested the ability of a range
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