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74817

Sigma-Aldrich

FITC-CM-Dextran

average mol wt 150,000

Synonyme(s) :

FITC-CM-Dextran 150, Fluorescein isothiocyanate–Carboxymethyl–Dextran

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About This Item

Code UNSPSC :
12352108
Nomenclature NACRES :
NA.32

Source biologique

synthetic

Niveau de qualité

100

Conjugué

FITC conjugate

Forme

powder or crystals

Poids mol.

average mol wt 150,000

Composition

carboxymethyl content, 3-7%

Ampleur du marquage

0.001-0.020 mol FITCmol glucose

Fluorescence

λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0

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Description générale

FITC-CM-Dextran, also known as Fluorescein isothiocyanate–Carboxymethyl–Dextran, is an anionic fluorescent probe. The carboxyl group provides the negative charge, which improves the overall permeability of the molecule. It is supplied as a yellow powder that is freely soluble in water and electrolyte solutions. FITC-CM-Dextran is insoluble in most organic samples such as ethanol, methanol, acetone, and chloroform.

FITC-CM-Dextran is manufactured by reacting selected dextran fractions with an activated carboxymethyl derivative in alkali, whereby O-carboxymethyl groups are introduced along the dextran chain.

Application

FITC-CM-dextran is used to study drug intake and delivery mechanisms in HeLa cell lines. FITC-CM-Dextran was chosen due to its high water solubility and negative charge.

It is also a suitable molecule to be used in encapsulation studies for polymersomal drug delivery systems or Ps DDS . FITC-CM-Dextran is a biocompatible molecule used as a starting material in several pharmaceutical and diagnostic applications.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Marco Romano et al.
Oncoimmunology, 6(10), e1345402-e1345402 (2017-11-11)
Myelofibrosis (MF) is a clonal neoplasia associated with chronic inflammation due to aberrant cytokine production. Mutations in Janus Kinase-2 (JAK2), calreticulin (CALR) and myeloproliferative leukemia protein (MPL) genes have been recently associated to MF and they all activate the JAK/STAT
Chloe Martin et al.
International journal of pharmaceutics, 481(1-2), 1-8 (2015-01-17)
The field of therapeutics is evolving to include a greater proportion of higher molecular weight, hydrophilic biological compounds. To cater for this new era in healthcare the concomitant development of appropriate drug delivery systems is essential to aid cellular permeation.

Articles

FITC-labelled polysaccharides

Additional information about FITC-labelled polysaccarides including FITC-Dextran, FITC-DEAE-dextran (FDD), FITC-carboxymethyl-dextran (FCM-Dextran). This page discusses the impact of weight-average molecular weight on the respective molecule dimensions and other physical properties

FITC-labelled polysaccharides

Additional information about FITC-labelled polysaccarides including FITC-Dextran, FITC-DEAE-dextran (FDD), FITC-carboxymethyl-dextran (FCM-Dextran). This page discusses the impact of weight-average molecular weight on the respective molecule dimensions and other physical properties

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