50239

Gly-Gly-Gly

≥99.0% (NT), suitable for ligand binding assays, BioUltra

• Synonyme(s) : Glycyl-glycyl-glycine, Triglycine
• Formule linéaire : NH₂CH₂CONHCH₂CONHCH₂COOH
• Numéro CAS: 556-33-2
• Poids moléculaire : 189.17
• Beilstein: 1711130
• Numéro CE : 209-122-0
• Numéro MDL: MFCD00036223
• Code UNSPSC : 12352209
• ID de substance PubChem : 57651245
• Nomenclature NACRES : NA.26

Propriétés

• Nom du produit: Gly-Gly-Gly, BioUltra, ≥99.0% (NT)
• Gamme de produits: BioUltra
• Niveau de qualité: 100
• Essai: ≥99.0% (NT)
• Forme: powder
• Technique(s): ligand binding assay: suitable
• Impuretés: insoluble matter, passes filter test
• Résidus de calcination: ≤0.1% (as SO₄)
• Perte: ≤0.5% loss on drying, 110 °C
• Couleur: white
• pH: 4.5-6.0 (25 °C, 0.5 M in H₂O)
• Solubilité: H₂O: 0.5 M at 20 °C, clear, colorless
• Traces d'anions: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤50 mg/kg
• Traces de cations: Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤50 mg/kg; Bi: ≤5 mg/kg; Ca: ≤20 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• λ: 0.5 M in H₂O
• Absorption UV: λ: 260 nm A_max: 0.15; λ: 280 nm A_max: 0.10
• Chaîne SMILES: NCC(=O)NCC(=O)NCC(O)=O
• InChI: 1S/C6H11N3O4/c7-1-4(10)8-2-5(11)9-3-6(12)13/h1-3,7H2,(H,8,10)(H,9,11)(H,12,13)
• Clé InChI: XKUKSGPZAADMRA-UHFFFAOYSA-N

Description

Amino Acid Sequence

Gly-Gly-Gly

Description générale

Gly-Gly-Gly or triglycine is a flexible peptide linker with three glycine residues linked by peptide bonds in a linear sequence. Gly-linkers link multiple domains in a single protein without affecting the function of each domain.

Application

<ul>
<li><strong>Targeting PEPT1: a novel strategy to improve the antitumor efficacy of doxorubicin in human hepatocellular carcinoma therapy:</strong> Research explores Gly-Gly-Gly peptides as potential enhancers for drug transport efficiency, positioning them as valuable tools in clinical diagnostic peptide development for targeted cancer therapies (Gong et al., 2017).</li>
<li><strong>Iminopyridine complexes of manganese, rhenium, and molybdenum derived from amino ester methylserine and peptides Gly-Gly, Gly-Val, and Gly-Gly-Gly: self-assembly of the peptide chains:</strong> This study demonstrates the use of Gly-Gly-Gly in the synthesis of complex metal-peptide frameworks for potential use in high-purity peptide applications in IVD manufacturing (&Aacute;lvarez et al., 2012).</li>
</ul>

Actions biochimiques/physiologiques

Substrate for reproducible serum protein measurements by the biuret reaction and for the assay of aminotripeptidases.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)