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Y0001584

Desloratadine

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine, Clarinex®

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About This Item

Formule empirique (notation de Hill):
C19H19ClN2
Numéro CAS:
100643-71-8
Poids moléculaire :
310.82
Numéro MDL:
MFCD00871949
Code UNSPSC :
41116107
ID de substance PubChem :
329831495
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

desloratadine

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1

InChI

1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2

Clé InChI

JAUOIFJMECXRGI-UHFFFAOYSA-N

Informations sur le gène

human ... HRH1(3269)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Desloratadine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Informations légales

Clarinex is a registered trademark of Schering Corp.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Y0001582

Desloratadine, European Pharmacopoeia (EP) Reference Standard

1173042

Desloratadine, United States Pharmacopeia (USP) Reference Standard

1173053

Desloratadine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1173086

Desloratadine Related Compound B, United States Pharmacopeia (USP) Reference Standard

1173064

Desloratadine Related Compound F, United States Pharmacopeia (USP) Reference Standard

PHR2314

Desloratadine Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2316

Desloratadine Related Compound F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2315

Desloratadine Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

390.2 °F - Pensky-Martens closed cup

Point d'éclair (°C)

199 °C - Pensky-Martens closed cup

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Faraz Kazmi et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(4), 523-533 (2015-01-18)
Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating long-lasting antihistamine that is widely used for the treatment of allergic rhinitis and chronic idiopathic urticaria. For over 20 years, it has remained a mystery as to which
Eva Wex et al.
PloS one, 9(12), e116166-e116166 (2014-12-30)
Mast cells are central effector cells in allergic asthma and are augmented in the airways of asthma patients. Attenuating mast cell degranulation and with it the early asthmatic response is an important intervention point to inhibit bronchoconstriction, plasma exudation and
Shigeru Hishinuma et al.
Biochemical pharmacology, 91(2), 231-241 (2014-07-30)
Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human
Jung Yeon Kim et al.
Biomedical chromatography : BMC, 29(3), 465-474 (2014-08-01)
The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The limits of detection and quantitation of the method ranged from 1.5 to 2.5
Yoko Nagaya et al.
Drug metabolism and pharmacokinetics, 29(5), 419-426 (2014-05-09)
In central nervous system drug discovery, cerebrospinal fluid (CSF) drug concentration (C(CSF)) has been widely used as a surrogate for unbound brain concentrations (C(u,brain)). However, previous rodent studies demonstrated that when drugs undergo active efflux by transporters, such as P-glycoprotein

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