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Y0000639

Cladribine

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

2-Chloro-2′-deoxyadenosine, CdA, Cladribine

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About This Item

Formule empirique (notation de Hill) :
C10H12ClN5O3
Numéro CAS:
4291-63-8
Poids moléculaire :
285.69
Numéro MDL:
MFCD00153939
Code UNSPSC :
41116107
ID de substance PubChem :
329831069
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

cladribine

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

−20°C

Chaîne SMILES 

Nc1nc(Cl)nc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO)O3

InChI

1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1

Clé InChI

PTOAARAWEBMLNO-KVQBGUIXSA-N

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Cladribine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Mentions de danger

H301,H341,H361fd,H372

Classification des risques

Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Francesco Lauria et al.
Leukemia & lymphoma, 52 Suppl 2, 34-37 (2011-04-21)
Nucleoside derivative cladribine treatment in hairy cell leukemia (HCL) is a rare example of treatment success in cancer. In fact, HCL is generally responsive to single-agent cladribine and only a minority of patients are refractory. Cladribine was originally administered intravenously
Jack C Sipe
Expert review of neurotherapeutics, 10(3), 365-375 (2010-03-02)
Cladribine, a synthetic deoxyadenosine analog, is an oral immunomodulatory agent that produces targeted, sustained reduction of T and B lymphocytes. This mechanism of action provides the rationale for use in relapsing-remitting multiple sclerosis (MS) in a short-course annual dosing regimen.
Clemens Warnke et al.
Drug design, development and therapy, 4, 117-126 (2010-08-07)
Orally available disease-modifying drugs for relapsing-remitting multiple sclerosis (MS) represent an unmet need for this chronic and debilitating disease. Among 5 currently investigated drugs at phase 3 clinical stage, promising efficacy data for fingolimod and oral cladribine have recently been
Martin S Tallman
Leukemia & lymphoma, 52 Suppl 2, 65-68 (2011-04-06)
Hairy cell leukemia (HCL) is a highly treatable, but generally incurable B-cell lymphoproliferative disorder with a long natural history. The purine analogs cladribine and pentostatin are the treatments of choice and both induce complete remission (CR) by peripheral blood counts
Thomas P Leist et al.
Clinical neuropharmacology, 34(1), 28-35 (2011-01-19)
Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central nervous system. The inflammation is driven significantly by autoreactive lymphocytes, which recruit cells of the innate immune system such as macrophages that contribute to subsequent tissue damage, ultimately resulting
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