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PHR1375

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Ketoprofen

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

Ketoprofen, KP, 2-(3-Benzoylphenyl)propionic acid

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About This Item

Formule empirique (notation de Hill):
C16H14O3
Numéro CAS:
Poids moléculaire :
254.28
Numéro CE :
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24

Qualité

certified reference material
pharmaceutical secondary standard

Niveau de qualité

Agence

traceable to BP 668
traceable to Ph. Eur. K2000000
traceable to USP 1356632

Famille d'API

ketoprofen

CofA (certificat d'analyse)

current certificate can be downloaded

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-30°C

Chaîne SMILES 

CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2

InChI

1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)

Clé InChI

DKYWVDODHFEZIM-UHFFFAOYSA-N

Informations sur le gène

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Description générale

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Ketoprofen is an active pharmaceutical compound used as a non-steroidal anti-inflammatory drug (NSAID). It is essentially a non-narcotic drug extensively utilized for mild to moderate pain relief.

Application

Ketoprofen may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography and spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Actions biochimiques/physiologiques

Composé anti-inflammatoire non stéroïdien spécifique de la COX-1.

Remarque sur l'analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Autres remarques

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Note de bas de page

To see an example of a Certificate of Analysis for this material enter LRAC3470 in the slot below. This is an example certificate only and may not be the lot that you receive.

Produits recommandés

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictogrammes

Skull and crossbonesEnvironment

Mention d'avertissement

Danger

Mentions de danger

Classification des risques

Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Choose from one of the most recent versions:

Certificats d'analyse (COA)

Lot/Batch Number

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Development and validation of a stability-indicating high-performance liquid chromatographic assay for ketoprofen topical penetrating gel
Bempong DK and Bhattacharyya L
Journal of Chromatography A, 1073(1-2), 341-346 (2005)
UV-spectrophotometric determination of ketoprofen and paraben in a gel preparation by partial least-squares calibration
Blanco M, et al.
Fresenius Journal of Analytical Chemistry, 357(7), 967-972 (1997)
Simultaneous HPLC determination of ketoprofen and its degradation products in the presence of preservatives in pharmaceuticals
Dvorak J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 36(3), 625-629 (2004)
H Bagheri et al.
Drug safety, 22(5), 339-349 (2000-06-01)
The topical use of nonsteroidal anti-inflammatory drugs (NSAIDs), widely used for moderate acute and chronic painful conditions, is one of several strategies used to improve the tolerability profile of NSAIDs, particularly with regard to gastric and renal adverse effects. However
M Sugiura et al.
Contact dermatitis, 43(1), 16-19 (2000-07-21)
We report 4 cases of photocontact dermatitis due to ketoprofen, a non-steroidal anti-inflammatory drug derived from propionic acid. We carried out a skin biopsy to examine the amount of ketoprofen in the eruptive skin. We investigated the cross-reactions between tiaprofenic

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