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P1700000

Pilocarpine nitrate

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Pilocarpine nitrate salt

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About This Item

Formule empirique (notation de Hill):
C11H16N2O2 · HNO3
Numéro CAS:
148-72-1
Poids moléculaire :
271.27
Numéro Beilstein :
4171406
Numéro MDL:
MFCD00078497
Code UNSPSC :
41116107
ID de substance PubChem :
329820103
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

pilocarpine

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C

InChI

1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1

Clé InChI

PRZXEPJJHQYOGF-GNAZCLTHSA-N

Informations sur le gène

human ... CHRM1(1128) , CHRM3(1131)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Pilocarpine nitrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Pictogrammes

Flame over circleSkull and crossbones
GHS03,GHS06

Mention d'avertissement

Danger

Mentions de danger

H272,H302,H330

Classification des risques

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2

Code de la classe de stockage

5.1B - Oxidizing hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Marcele Jardim Pimentel et al.
Anticancer research, 34(4), 1993-1999 (2014-04-03)
There is controversy concerning the effect of pilocarpine in the reversal of radio-induced xerostomia; however, the tests are usually performed at the end of radiotherapy. The present study evaluated the radioprotective effects of pilocarpine when ingested during radiation treatment. Eleven
Barina Aqil et al.
Archives of pathology & laboratory medicine, 138(7), 920-922 (2014-02-27)
All positive screening of newborns for cystic fibrosis using the dried blood spot 2-tiered immunoreactive trypsinogen/DNA method requires subsequent sweat chloride testing for confirmation. Obtaining an adequate volume of sweat to measure chloride is a challenge for many cystic fibrosis
Yuan-yuan Zhang et al.
Acta pharmacologica Sinica, 35(9), 1137-1149 (2014-08-05)
The non-neuronal acetylcholine system (NNAS) in endothelial cells participates in modulating endothelial function, vascular tone, angiogenesis and inflammation, thus plays a critical role in cardiovascular diseases. In this study, we used a proteomic approach to study potential downstream receptor-effectors of
Lin He et al.
Experimental eye research, 125, 244-255 (2014-07-02)
This study was undertaken to understand the role of anterior chamber pressure (ACP) during pharmacological and Edinger-Westphal (EW) stimulated accommodation in anesthetized monkeys. Experiments were performed on one iridectomized eye each of 7 anesthetized adolescent rhesus monkeys. Accommodation was induced
Mussie G Hadera et al.
Journal of neurochemistry, 129(1), 107-119 (2013-11-19)
Triheptanoin, the triglyceride of heptanoate, is anticonvulsant in various epilepsy models. It is thought to improve energy metabolism in the epileptic brain by re-filling the tricarboxylic acid (TCA) cycle with C4-intermediates (anaplerosis). Here, we injected mice with [1,2-(13) C]glucose 3.5-4
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