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D0100000

4-aminophényl sulfone

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

DDS

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About This Item

Formule linéaire :
(H2NC6H4)2SO2
Numéro CAS:
80-08-0
Poids moléculaire :
248.30
Numéro Beilstein :
788055
Numéro MDL:
MFCD00007887
Code UNSPSC :
41116107
ID de substance PubChem :
329798581
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Agence

EP Reference Standard

Famille d'API

dapsone

Fabricant/nom de marque

EDQM

Pf

175-177 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2

InChI

1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2

Clé InChI

MQJKPEGWNLWLTK-UHFFFAOYSA-N

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dapsone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

Health hazardExclamation markEnvironment
GHS08,GHS07,GHS09

Mention d'avertissement

Danger

Mentions de danger

H302,H360F,H371,H373,H411

Classification des risques

Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 1B - STOT RE 2 - STOT SE 2

Organes cibles

Blood, Blood,spleen,Liver

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Mira Stotland et al.
American journal of clinical dermatology, 10(4), 221-227 (2009-06-06)
Dapsone, a synthetic sulfone that has been available for over 60 years, has been used to treat a myriad of cutaneous disorders. Prior to the general acceptance of isotretinoin, oral dapsone had been reported to be effective in the treatment
Amanda Pickert et al.
Expert opinion on pharmacotherapy, 10(9), 1515-1521 (2009-06-10)
Oral dapsone has been available for over 60 years. Its first clinical use was discovered in 1945, when it was found to be efficacious in inhibiting the progression of leprosy. The combined antibacterial and anti-inflammatory pharmacologic activities of dapsone have
R E Kast et al.
British journal of neurosurgery, 26(6), 813-817 (2012-05-04)
Lopez-Gomez et al. recently published remarkable but mechanistically unexplained empirical evidence that the old antibiotic dapsone has antiepileptic activity. We addressed the question "Why should a sulfone antibiotic reduce seizures?". We report here our conclusions based on data from past
Maria Lorenz et al.
Acta dermato-venereologica, 92(2), 194-199 (2012-02-07)
Dapsone is widely used in the treatment of leprosy and several chronic inflammatory dermatological conditions. Hypersensitivity reactions to dapsone are potentially fatal adverse drug reactions with unknown prevalence and risk factors. We performed a systematic review covering all reported cases
Jennifer Tan et al.
Journal of cutaneous medicine and surgery, 10(2), 92-95 (2007-01-24)
Mesotherapy is a procedure involving the injection of substances into the dermis and subcutaneous tissue. Used in Europe for decades in the treatment of various medical conditions and cosmetic fat dissolution, the technique only recently became widely available in the
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