938785

Sodium tert-butoxide ChemBeads

• Synonyme(s) : NaOtBu, Sodium 2-methylpropan-2-olate, Sodium t-butoxide, Sodium tert-butanolate, Sodium tert-butylate
• Numéro CAS: 865-48-5
• Numéro MDL: MFCD00040575
• Code UNSPSC : 12352100

Propriétés

• Forme: solid ()
• Niveau de qualité: 100
• Composition: loading of base, 14-16 wt. %
• Chaîne SMILES: [Na+].CC(C)(C)[O-]
• InChI: 1S/C4H9O.Na/c1-4(2,3)5;/h1-3H3;/q-1;+1
• Clé InChI: MFRIHAYPQRLWNB-UHFFFAOYSA-N

Description

Application

Sodium tert-butoxide may be used as a safe and effective alternative to sodium hydride for the coupling of hydroxyethyl adenine with diethyl p-toluenesulfonyloxymethanephosphonate to form 9-[2-(diethylphosphonomethoxy)ethyl]adenine (diethyl-PMEA), which is a key intermediate to prepare adefovir dipivoxil.
It can also be used:
- To facilitate the coupling of aryl halides with benzene derivatives in the presence of 10-phenanthroline derivative.
- To activate first-row transition-metal pre-catalysts.
- As a base for the amination of aryl chlorides in the presence of a novel palladacyclic precatalyst.
For general uses, product is also available in powdered form (359270)

Caractéristiques et avantages

ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.

Informations sur la sécurité

• Pictogrammes: GHS02,GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H228,H251,H314
• Conseils de prudence: P210 - P235 - P260 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Classification des risques: Eye Dam. 1 - Flam. Sol. 1 - Self-heat. 1 - Skin Corr. 1B
• Risques supp: EUH014
• Code de la classe de stockage: 4.2 - Pyrophoric and self-heating hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3