936693

tBuXPhos ChemBeads

• Synonyme(s) : 2-Di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl ChemBeads, tert-Butyl Xphos ChemBeads, t-Bu Xphos ChemBeads, tBuXPhos
• Formule empirique (notation de Hill): C₂₉H₄₅P
• Numéro CAS: 564483-19-8
• Poids moléculaire : 424.64
• Numéro MDL: MFCD06411306
• Code UNSPSC : 12352100

Propriétés

• Niveau de qualité: 100
• Forme: solid
• Composition: , 4-6 wt. % (loading)
• Pertinence de la réaction: reagent type: ligand
• Chaîne SMILES: CC(C)(C)P(C(C)(C)C)C1=C(C2=C(C(C)C)C=C(C(C)C)C=C2C(C)C)C=CC=C1
• InChI: InChI=1S/C29H45P/c1-19(2)22-17-24(20(3)4)27(25(18-22)21(5)6)23-15-13-14-16-26(23)30(28(7,8)9)29(10,11)12/h13-21H,1-12H3
• Clé InChI: SACNIGZYDTUHKB-UHFFFAOYSA-N

Description

Description générale

The ChemBeads product of tBuXPhos [2-Di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. Loaded on glass beads for use in high-throughput expermentation (HTE).

Application

tBuXPhos has been used as a ligand in many C-N and C-O bond forming reactions, as well many others including:
- The palladium-catalyzed Tsuji-Trost substitution and cross-coupling of benzylic fluorides.
- The palladium-catalyzed C-N cross-coupling of sulfinamides and aryl halides.
- The protoboration of alkynes.
- ArF-alkynyl coupling with fluorinated aryls.
- The Ni & Ni/Pd reductive coupling of lignan-derived aromatics to biobased platicizers.
- The palladium-catalyzed fluorination of cyclic vinyl triflates.
ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.
For general uses, product is also available in powdered form (638080)

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable