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50744

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Dimethyl fumarate

certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

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About This Item

Formule linéaire :
CH3OCOCH=CHCOOCH3
Numéro CAS:
Poids moléculaire :
144.13
Numéro Beilstein :
774590
Numéro CE :
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24

Qualité

certified reference material
TraceCERT®

Niveau de qualité

Gamme de produits

TraceCERT®

Durée de conservation

limited shelf life, expiry date on the label

Fabricant/nom de marque

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Point d'ébullition

192-193 °C (lit.)

Pf

102-106 °C (lit.)

Application(s)

agriculture
environmental

Format

neat

Chaîne SMILES 

[H]\C(=C(\[H])C(=O)OC)C(=O)OC

InChI

1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+

Clé InChI

LDCRTTXIJACKKU-ONEGZZNKSA-N

Informations sur le gène

human ... KEAP1(9817)

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Description générale

Dimethyl fumarate is a novel oral therapeutic agent, which can be used for patients suffering from relapsing-remitting multiple sclerosis. It shows an effective inhibition of mould in bread and can also serve as a potential candidate for the treatment of psoriasis, a chronic autoimmune condition.
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Informations légales

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

Exclamation markEnvironment

Mention d'avertissement

Warning

Mentions de danger

Classification des risques

Acute Tox. 4 Dermal - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Certificats d'analyse (COA)

Lot/Batch Number

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Les clients ont également consulté

Reactivity of dimethyl fumarate and methylhydrogen fumarate towards glutathione and N-acetyl-L-cysteine?preparation of S-substituted thiosuccinic acid esters
Schmidt.JT, et al.
Bioorganic & Medicinal Chemistry, 15, 333-342 (2007)
Effects of dimethyl fumarate on neuroprotection and immunomodulation
Albrecht P, et al.
Journal of Neuroinflammation, 163, 9-9 (2012)
Shoe contact dermatitis from dimethyl fumarate: clinical manifestations, patch test results, chemical analysis, and source of exposure
Gimenez-Arnau A, et al.
Contact Dermatitis, 61, 249-260 (2009)
Frieder Kees
Expert opinion on pharmacotherapy, 14(11), 1559-1567 (2013-05-24)
Dimethyl fumarate (DMF) has been used as fungicide, but oral DMF activates anti-inflammatory and anti-oxidative pathways that are beneficial in the treatment of psoriasis. BG-12, a specific formulation of DMF, has been approved very recently for the treatment of relapsing-remitting
Ralf A Linker et al.
Current neurology and neuroscience reports, 13(11), 394-394 (2013-09-26)
Dimethyl fumarate is an orally available treatment option for relapsing-remitting multiple sclerosis (MS) in a new formulation with improved gastroenteric coating. The mode of action comprises immunomodulatory effects and an activation of nuclear (erythroid-derived 2) related factor mediated antioxidative response

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