33894

Clotrimazole

VETRANAL^®, analytical standard

• Synonyme(s) : 1-(o-Chloro-α,α-diphenylbenzyl)imidazole, 1-(o-Chlorotrityl)imidazole, 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole
• Formule empirique (notation de Hill): C₂₂H₁₇ClN₂
• Numéro CAS: 23593-75-1
• Poids moléculaire : 344.84
• Numéro CE : 245-764-8
• Numéro MDL: MFCD00057220
• Code UNSPSC : 41116107
• ID de substance PubChem : 329754531
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: analytical standard
• Gamme de produits: VETRANAL^®
• Durée de conservation: limited shelf life, expiry date on the label
• Technique(s): HPLC: suitable; gas chromatography (GC): suitable
• Spectre d'activité de l'antibiotique: fungi
• Application(s): agriculture; environmental
• Format: neat
• Mode d’action: protein synthesis | interferes
• Chaîne SMILES: Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
• InChI: 1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
• Clé InChI: VNFPBHJOKIVQEB-UHFFFAOYSA-N

Description

Description générale

Clotrimazole, a non-toxic, systemic, imidazole derivative with broad-spectrum antimycotic activity, is primarily used in the treatment of oropharyngeal candidiasis.

Its mode of action involves the inhibition of ergosterol synthesis, which leads to structural and functional damage of the cell membrane.

Application

Clotrimazole may be used as a reference standard for the determination of the analyte in topical creams and ear drops by reversed-phase high-performance liquid chromatographic (RP-HPLC) method.

Clotrimazole may be used as an analytical reference standard for the determination of the analyte in:

• Milk samples using solid-phase extraction followed by high-performance liquid chromatography (SPE-HPLC).
• Environmental water samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Informations légales

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315,H319,H410
• Conseils de prudence: P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves