SCT264

BioTracker^™ Mitophagy Live Cell Probe

Human

• Synonyme(s) : mitochondrial degradation probe, mitophagy detection, mitophagy probe
• Code UNSPSC : 41106514
• Nomenclature NACRES : NB.12

Propriétés

• product name: BioTracker^™ Mitophagy Live Cell Probe,
• Source biologique: human
• Niveau de qualité: 100
• Forme: lyophilized solid
• Conditionnement: vial of 15 μg
• Fabricant/nom de marque: Millipore
• Technique(s): cell culture | stem cell: suitable
• Conditions d'expédition: 2-8°C
• Température de stockage: 2-8°C

Description

Description générale

The Mitophagy probe accumulates in intact mitochondria, where it is immobilized by chemical bonds and exhibits a weak fluorescence under normal conditions. When mitophagy is induced, the damaged mitochondria fuse with the lysosome, increasing fluorescence


SPECTRAL PROPERTIES
λex: 530 nm
λem: 700 nm

A 100 uM stock solution of the mitophagy probe is created by dissolving 50 uL DMSO to one tube (5 ug) of mitophagy dye.
A typical working solution concentration is 1 nM.

Caractéristiques et avantages

SCT264 live cell mitophagy detection probe accumulates and is immobilized on intact mitochondria, which fuse to the lysosome after mitophagy is induced, causing the probe to fluoresce brightly. Mitophagy has been associated with the accumulation of dysfunctional mitochondria in diseases such Alzheimer′s and Parkinson′s.

Description de la cible

Mitochondria play an essential role in cells for the production of energy. Mitophagy, or the removal of damaged mitochondria via autophagy, has been connected to Alzheimer s and Parkinson s disease induced by the accumulation of depolarized mitochondria. Mitophagy serves as a dedicated elimination system that removes mitochondria whose dysfunction may be caused by oxidative stress and DNA damage. Mitochondria destined for autophagy are sequestered into the autophagosome, fused to the lysosome, and digested.

Forme physique

purple solid

Stockage et stabilité

Store at 2 - 8 °C, protected from light.

Autres remarques

This far red live cell probe for mitophagy detection fluoresces brightly when damaged mitochondria enter the acidic environment of the lysosome.

Informations légales

BioTracker is a trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable