SCT246

BioTracker BioCyTASQ G-Quadruplex (G4) Cell Probe

• Synonyme(s) : G quadruplex probe, G4 ligand, G4 probe, G4 tetrad probe, Live Cell Imaging Probe
• Code UNSPSC : 41106514
• Nomenclature NACRES : NA.47

Propriétés

• Conditionnement: vial of 1 mg
• Niveau de qualité: 100
• Fabricant/nom de marque: Millipore
• Mode de croissance: N/A
• Technique(s): DNA sequencing: suitable; RNA extraction: suitable; nucleic acid detection: suitable
• Méthode de détection: fluorometric
• Conditions d'expédition: dry ice
• Température de stockage: −20°C

Description

Application

G-quadruplexes are four-stranded structures comprising stacked G tetrads (G4) formed within certain guanine-rich nucleic acid sequences. G-quadruplexes are enriched in open chromatin regions but are also present in the nucleolus and cytoplasm. The formation of G4 structures is dynamic and cell-type specific, suggestive of interaction with transcription factors and other proteins. For this reason G-quadruplexes have garnered intense interest for their potential role in transcriptional regulation.

The BioTracker^™ BioCyTASQ G-quadruplex G4 cell probe is optimized for detection of G-quadruplexes. BioCyTASQ utilizes the template-assembled synthetic G-quartets (TASQ) concept as a biomimetic ligand for G-quadruplexes, a design which results in high specificity for folded G4.

References
1. Nat. Chem. 2021, 13(7): 626-633
2. ACS Chem Biol. 2021, 16(5): 905-914

Purity: > 98% confirmed by HPLC, HNMR, LC-MS and elemental analysis.

Caractéristiques et avantages

BioCyTASQ detects ribosomal RNA associated with perinuclear rough ER regions. BioCyTASQ is suitable for G4 capture pull-down assays as well as cellular imaging.2 BioCyTASQ G4 probe is not recommended for live-cell imaging applications. The biotinylated BioTracker BioCyTASQ G-quadruplex G4 cell probe makes is a powerful tool for biochemical and cellular analysis of G4 by fluorescent detection when used with a fluorescent streptavidin.

Forme physique

Lyophilized. White solid.

Stockage et stabilité

Store BioTracker BioCyTASQ G-quadruplex G4 cell probe at -20°C, desiccated and protected from light

Autres remarques

Fluorescent detection of nucleic acid G4 quadruplexes in cells and tissues

Informations légales

BioTracker is a trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable