MABS466

Anti-Trpv4 Antibody, clone 1B2.6

clone 1B2.6, from mouse

• Synonyme(s) : Trpv4, Transient receptor potential cation channel subfamily V member 4, TrpV4, Osm-9-like TRP channel 4, OTRPC4, Transient receptor potential protein 12, TRP12, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, VRL-2, Vanilloid recep
• Code UNSPSC : 12352203
• eCl@ss : 32160702

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: purified antibody
• Type de produit anticorps: primary antibodies
• Clone: 1B2.6, monoclonal
• Espèces réactives: mouse, human
• Technique(s): immunocytochemistry: suitable; western blot: suitable
• Isotype: IgG2aκ
• Numéro d'accès NCBI: NP_001170899
• Numéro d'accès UniProt: Q9HBA0
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... TRPV4(59341)

Description

Description générale

Transient receptor potential cation channel subfamily V member 4 is a multitransmembrane non-selective cation channel encoded by the TRPV4 (also known as CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VR-OAC, VRL-2, VRL2, VROAC) gene and belong to the OSM9-like transient receptor potential channel (OTRPC) subfamily within the transient receptor potential (TRP)3 superfamily of channels. Ankyrin (ANK) repeats/domains are shown to be important for functional channel expression, and ANK domain mutations are found in patients suffering from Spinal muscular atrophies (SMA, also known as hereditary motor neuropathies) and hereditary motor and sensory neuropathies (HMSN). (PMID 16293632, 20037587, 20037588).

Spécificité

This antibody is expected to react to all isoforms.

Immunogène

GST-tagged recombinant protein corresponding to human Trpv4.

Application

Anti-Trpv4 Antibody, clone 1B2.6 is an antibody against Trpv4 for use in Western Blotting and Immunocytochemistry.

Immunocytochemistry Analysis: 10 µg/mL from a representative lot detected Trpv4 in NIH/3T3 cells.

Research Category
Signaling

Research Sub Category
Signaling Neuroscience

Qualité

Evaluated by Western Blotting in SK-MEL-28 cell lysate.

Western Blotting Analysis: 0.1 µg/mL of this antibody detected Trpv4 in 10 µg of SK-MEL-28 cell lysate.

Description de la cible

~86-98 kDa observed. Uniprot describes 6 isoforms produced by alternative splicing ranging from ~86 to 98 kDa Uncharacterized band(s) may appear in some lysates.

Forme physique

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Autres remarques

Concentration: Please refer to lot specific datasheet.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable