MAB4051
Anti-Angiotensin Converting Enzyme Antibody, clone 9B9
clone 9B9, Chemicon®, from mouse
Synonyme(s) :
ACE, CD143, DCP1, Peptidyl-dipeptidase A, Peptidase P
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Niveau de qualité
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
9B9, monoclonal
Espèces réactives
hamster, feline, human, monkey, rat
Fabricant/nom de marque
Chemicon®
Technique(s)
ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Isotype
IgG1
Adéquation
not suitable for immunohistochemistry (Paraffin)
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... AGT(183)
Description générale
The previously assigned protein identifier P22966 has been merged into P12821. Full details can be found on the UniProt database.
Spécificité
Angiotensin-converting enzyme [ACE] (N-terminal), no reactivity to testicular/germinal form of human ACE (90kDa isoform)
Immunogène
Angiotensin-converting enzyme from human lung
Application
Anti-Angiotensin Converting Enzyme Antibody, clone 9B9 detects level of Angiotensin Converting Enzyme & has been published & validated for use in ELISA, IP, WB, IC, IH.
Immunohistochemistry (Danilov et al., 1987; Falkenhahn et al., 1995; Morrell et al., 1995) : 1:1,000 on fresh frozen or 4% paraformaldehyde fixed tissues. Does not work on paraffin embedded tissue.
Immunocytochemistry: 1:100. Reacts with endothelial cell, macrophages (activated) and THP1 cells (monocyte line).
Immunoblotting: 1:100: ~170-180kDa isoform, reducing conditions.
Immunoprecipitation: 1:1,000-1:10,000
ELISA : 1:1,000
Visualization of lung vessels (Danilov et al., 1989; Klibanov et al., 1988; Hiemisch et al., 1993)
Antibody mediated drug delivery into the lung (Danilov et al., 1991, 1994; Muzykantov et al., 1994, 1996)
Estimation of lung vessel injury (Muzykantov et al., 1991; Atochina et al., 1992)
Structure-function of ACE (Danilov et al., 1994)
Optimal working dilutions must be determined by the end user.
Immunocytochemistry: 1:100. Reacts with endothelial cell, macrophages (activated) and THP1 cells (monocyte line).
Immunoblotting: 1:100: ~170-180kDa isoform, reducing conditions.
Immunoprecipitation: 1:1,000-1:10,000
ELISA : 1:1,000
Visualization of lung vessels (Danilov et al., 1989; Klibanov et al., 1988; Hiemisch et al., 1993)
Antibody mediated drug delivery into the lung (Danilov et al., 1991, 1994; Muzykantov et al., 1994, 1996)
Estimation of lung vessel injury (Muzykantov et al., 1991; Atochina et al., 1992)
Structure-function of ACE (Danilov et al., 1994)
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Hormones & Receptors
Hormones & Receptors
Forme physique
Format: Purified
Purified immunoglobulin. Liquid in PBS, pH 7.4, 150 mM NaCl containing 0.05% sodium azide.
Stockage et stabilité
Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informations légales
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Structure-function analysis of angiotensin I-converting enzyme using monoclonal antibodies. Selective inhibition of the amino-terminal active site.
Danilov, S, et al.
The Journal of Biological Chemistry, 269, 26806-26814 (1994)
Lung is the target organ for a monoclonal antibody to angiotensin-converting enzyme.
Danilov, S M, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 64, 118-124 (1991)
V V Petrov et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 1(4), 342-352 (2002-04-23)
Appearance of angiotensin-converting enzyme (ACE) in fibrotic tissue can be the result of the action either of one particular growth factor or of cross-talk between multiple factors. Transforming growth factor-beta1 (TGF-beta(1)) is an effective inducor of the differentiation of cultured
Immunohistochemical study of angiotensin-converting enzyme in human tissues using monoclonal antibodies.
Danilov, S M, et al.
Histochemistry, 87, 487-490 (1987)
N W Morrell et al.
The Journal of clinical investigation, 96(4), 1823-1833 (1995-10-01)
Previous studies suggest that while lung angiotensin converting enzyme (ACE) activity is reduced during chronic hypoxia, inhibitors of ACE attenuate hypoxic pulmonary hypertension. In an attempt to explain this paradox we investigated the possibility that whole lung ACE activity may
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