ABE91

Anti-JMJD8 Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : JMJD, JmjC domain-containing protein 8, Jumonji domain-containing protein 8
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Produit purifié par: affinity chromatography
• Espèces réactives: human, pig, horse
• Réactivité de l'espèce (prédite par homologie): porcine (based on 100% sequence homology), canine (based on 100% sequence homology), equine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology)
• Technique(s): western blot: suitable
• Numéro d'accès NCBI: NP_001005920.2
• Numéro d'accès UniProt: Q96S16
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... JMJD8(339123)

Description

Description générale

Covalent modification of histones plays critical role in regulating chromatin structure and transcription. JMJD8 is one member of the family of JmjC domain-containing histone demethylation (JHDM) enzymes. These proteins remove specific methyl marks from histones. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed. While two isoforms of JMJD8 have been described, further study is still required to clarify the roles and mechanisms of JMJD8 among other JHDM protein family members.

Immunogène

KLH-conjugated linear peptide corresponding to human JMJD8.

Application

Anti-JMJD8 Antibody is a Rabbit Polyclonal Antibody for detection of JMJD8 also known as Jumonji domain-containing protein 8 & has been validated in WB.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Histone Modifying Proteins

Qualité

Evaluated by Western Blot in HeLa nuclear extract.

Western Blot Analysis: 1 mg/mL of this antibody dected JMJD8 in 10 mg of HeLa nuclear extract.

Description de la cible

~37 kDa observed. Two isoforms with molecular weights of ~34 kDa and ~37 kDa have been described. An uncharacterized band at ~160 kDa may be observed in some lysates.

Forme physique

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
HeLa nuclear extract

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable