ABC841

Anti-Caspase-14 Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : Caspase-14, CASP-14
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Produit purifié par: affinity chromatography
• Espèces réactives: human
• Technique(s): immunohistochemistry: suitable; western blot: suitable
• Numéro d'accès UniProt: P31944
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... CASP14(23581)

Description

Description générale

Caspases are a family of cysteine proteases that can be divided into apoptotic and inflammatory caspase subfamilies. Caspase-14 exists as 2 subunits (p19 and p10) and is highly expressed in embryonic but not adult tissues. It is processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in the keratinocyte terminal differentiation, which is important for the formation of the skin barrier.

Spécificité

This antibody detects the pro-form of Caspase-14 as well as the large subunit cleaved form.

Immunogène

KLH-conjugated linear peptide corresponding to 16 amino acids near the C-terminus of human Caspase-14.

Application

Anti-Caspase-14 Antibody is a highly specific rabbit polyclonal antibody, that targets Caspase 14 & has been tested in western blotting & IHC.

Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected Caspase-14 in human liver tissue.

Qualité

Evaluated by Western Blotting in Jurkat cell lysate with and without blocking peptide.

Western Blotting Analysis: 1 μg/mL of this antibody detected Caspase-14 in Jurkat cell lysate with and without blocking peptide.

Description de la cible

~28 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable