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AB5702

Sigma-Aldrich

Anti-HES-1 Antibody

Chemicon®, from rabbit

Synonyme(s) :

Hairy 1

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

rodent, human, mouse

Fabricant/nom de marque

Chemicon®

Technique(s)

immunohistochemistry: suitable
western blot: suitable

Numéro d'accès NCBI

NM_005524.2

Numéro d'accès UniProt

Q14469

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... HES1(3280)
mouse ... Hes1(15205)

Description générale

Hes1 is a transcriptional repressor of genes that require a bHLH protein for their transcription. It may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Hes1 is expressed in developing neuroectodermal and endodermal endocrine tissues, and Hes1 deficient embryos show severe defects in neuronal development, as well as pancreatic hypoplasia.

Spécificité

Reactivity with other species has not been confirmed.
Recognizes HES-1 (Hairy family), a Helix-loop-helix class of transcription factor.

Immunogène

Synthetic peptide.

Application

Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

Neuronal & Glial Markers
This Anti-HES-1 Antibody is validated for use in IH, WB for the detection of HES-1.
Western Blot:
1:200-1:1,000 dilution using ECL.

Immunohistochemistry:
1:200-1:1,000 dilution of a previous lot worked.

Optimal working dilutions must be determined by the end user.

Description de la cible

29 kDa

Forme physique

ImmunoAffinity Purified
Purified rabbit polyclonal in buffer containing a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.

Stockage et stabilité

Stable for 1 year at -80ºC from date of receipt.

Remarque sur l'analyse

Control
Human neural stem cells, Raji cell lysate.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Combined in silico and in vivo analyses reveal role of Hes1 in taste cell differentiation.
Ota, MS; Kaneko, Y; Kondo, K; Ogishima, S; Tanaka, H; Eto, K; Kondo, T
PLoS Genetics null
An aquaporin 3-notch1 axis in keratinocyte differentiation and inflammation.
Guo, L; Chen, H; Li, Y; Zhou, Q; Sui, Y
Testing null
Notch signaling and Atoh1 expression during hair cell regeneration in the mouse utricle.
Wang GP, Chatterjee I, Batts SA, Wong HT, Gong TW, Gong SS, Raphael Y
Hearing Research null
Notch signaling in descending thoracic aortic aneurysm and dissection.
Zou, S; Ren, P; Nguyen, M; Coselli, JS; Shen, YH; LeMaire, SA
Testing null
Wen-Cheng Chung et al.
Oncoscience, 4(9-10), 131-138 (2017-11-17)
Kras mutations and increased Notch activation occur frequently in gallbladder cancer. However, their roles in gallbladder carcinogenesis have not been defined. This study was aimed at determining whether expression of mutant Kras was sufficient to induce gallbladder carcinoma and whether
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