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AB3232

Sigma-Aldrich

Anti-Low Density Lipoprotein Antibody, HOCL oxidized

serum, Chemicon®

Synonyme(s) :

LDL

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

serum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

human

Fabricant/nom de marque

Chemicon®

Technique(s)

ELISA: suitable
immunohistochemistry: suitable

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... LDLR(3949)

Spécificité

Reacts strongly and very specifically with HOCL-LDL. By time resolved fluorescence there was no detectable cross reactivity to unmodified LDL has been observed. However weak cross reactivity with MDA-LDL (20%), HNE-LDL (5%) and minimally modified LDL (5%) was observed. By Western blot no detectable cross reactivity to unmodified LDL was observed. Weak cross reactivity (<10%) was detected with MDA-LDL, HNE-LDL and 24 hour Cu2+ oxidized LDL. By ELISA the antibody bound to early and late stages of HOCL-LDL but only weakly (<5%) to several other modifications including MDA-LDL, Cu2-ox-LDL, MDA-HSA and native LDL.

Immunogène

Epitope: HOCL oxidized
Hypochlorite-modified LDL.

Application

Immunohistochemistry: 1:50-1:400

ELISA: 1:400-1:4,000

Optimal working dilutions must be determined by the end user.
Research Category
Metabolism
Research Sub Category
Lipid Metabolism & Weight Regulation
This Anti-Low Density Lipoprotein Antibody, HOCL oxidized is validated for use in ELISA, IH for the detection of Low Density Lipoprotein.

Forme physique

Rabbit serum.

Stockage et stabilité

Maintain lyophilized material at -20°C for up to 6 months After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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LOX-1 mediates vascular lipid retention under hypertensive state.
Nakano A, Inoue N, Sato Y, Nishimichi N, Takikawa K, Fujita Y, Kakino A, Otsui K et al.
Journal of Hypertension null
Feng-Shiun Shie et al.
The American journal of pathology, 164(4), 1173-1181 (2004-03-25)
Ischemic injury to brain is associated with both disruption of the blood-brain barrier and increased oxidative stress. Given the neurotoxicity associated with exposure to oxidized low-density lipoprotein (oxLDL) in vitro, we tested the hypothesis that oxLDL may be present in

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