AB3000
Anti-IP3 Receptor Type II Antibody
Chemicon®, from rabbit
Synonyme(s) :
Inositol 1,4,5-Trisphosphate Receptor
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Produit purifié par
affinity chromatography
Espèces réactives
mouse, hamster, human, monkey, rat
Fabricant/nom de marque
Chemicon®
Technique(s)
immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... ITPR2(3709)
Spécificité
Rabbit anti-Type II Inositol 1,4,5-Trisphosphate Receptor (IP3R) is directed against a synthetic peptide corresponding to the carboxy terminus of the rat Type II receptor. The antibody is reactive with Type II IP3R from rat, mouse, human, hamster, and monkey.
Immunogène
Synthetic peptide corresponding to the carboxy terminus of the rat Type II receptor
Application
Anti-IP3 Receptor Type II Antibody detects level of IP3 Receptor Type II & has been published & validated for use in IC, IF, IH, IP & WB.
Research Category
Signaling
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
GPCR, cAMP/cGMP & Calcium Signaling
Western blot: 1:50 - 1:100 (detects a 260 kDa band)
Immunofluorescence: 1:10 - 1:20
Immunoprecipitation
Immunocytochemistry: Known to give positive reactivity on AR4-2J, HL-60, COS-I, HEK-293, and RBL-2H3 cell lines.
Immunohistochemistry: Paraformaldehyde or methanol fixes are effective.
Optimal working dilutions must be determined by end user.
Immunofluorescence: 1:10 - 1:20
Immunoprecipitation
Immunocytochemistry: Known to give positive reactivity on AR4-2J, HL-60, COS-I, HEK-293, and RBL-2H3 cell lines.
Immunohistochemistry: Paraformaldehyde or methanol fixes are effective.
Optimal working dilutions must be determined by end user.
Forme physique
Affinity purified versus immobilized immunogen peptide. Liquid in PBS buffer, containing 0.05% BSA, 10% glycerol, 0.005% sodium azide. Caution: Sodium azide is hazardous. MSDS available upon request.
Stockage et stabilité
Maintain frozen at -20°C in undiluted aliquots for up to 12 months.
Informations légales
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Certificats d'analyse (COA)
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Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.
Chen, R; Valencia, I; Zhong, F; McColl, KS; Roderick, HL; Bootman, MD; Berridge et al.
The Journal of cell biology null
Mark Chalmers et al.
The Biochemical journal, 394(Pt 1), 57-66 (2005-11-09)
The size and number of IP3R (inositol 1,4,5-trisphosphate receptor) clusters located on the surface of the ER (endoplasmic reticulum) is hypothesized to regulate the propagation of Ca2+ waves in cells, but the mechanisms by which the receptors cluster are not
Type I, II, and III inositol 1,4,5-trisphosphate receptors are unequally susceptible to down-regulation and are expressed in markedly different proportions in different cell types.
Wojcikiewicz, R J
The Journal of Biological Chemistry, 270, 11678-11683 (1995)
D I Yule et al.
The Journal of biological chemistry, 272(14), 9093-9098 (1997-04-04)
A key event leading to exocytosis of pancreatic acinar cell zymogen granules is the inositol 1,4,5-trisphosphate (InsP3)-mediated release of Ca2+ from intracellular stores. Studies using digital imaging microscopy and laser-scanning confocal microscopy have indicated that the initial release of Ca2+
Takahiro Fujimoto et al.
International journal of molecular medicine, 30(6), 1287-1293 (2012-09-21)
KRAS-induced actin-interacting protein (KRAP), originally identified as one of the deregulated genes expressed in colorectal cancer, participates under physiological conditions in the regulation of systemic energy homeostasis and of the exocrine system. We have recently found that KRAP is a
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