8.52058

Fmoc-Tyr(PO₃H₂)-OH

Novabiochem^®

• Synonyme(s) : Fmoc-Tyr(PO₃H₂)-OH, N-α-Fmoc-O-phospho-L-tyrosine
• Formule empirique (notation de Hill): C₂₄H₂₂NO₈P
• Numéro CAS: 147762-53-6
• Poids moléculaire : 483.41
• Numéro MDL: MFCD00235902
• Code UNSPSC : 12352209

Propriétés

• Niveau de qualité: 200
• Gamme de produits: Novabiochem^®
• Pureté: ≥85.0% (acidimetric); ≥95% (TLC); ≥95.0% (HPLC)
• Forme: powder
• Capacité de réaction: reaction type: Fmoc solid-phase peptide synthesis
• Fabricant/nom de marque: Novabiochem^®
• Application(s): peptide synthesis
• Groupe fonctionnel: Fmoc
• Température de stockage: 15-25°C
• InChI: 1S/C24H22NO8P/c26-23(27)22(13-15-9-11-16(12-10-15)33-34(29,30)31)25-24(28)32-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22H,13-14H2,(H,25,28)(H,26,27)(H2,29,30,31)/t22-/m0/s1
• Clé InChI: AMXUJIHSMANWDW-QFIPXVFZSA-N

Description

Description générale

A useful derivative for the synthesis of phosphotyrosine peptides ^{[1,2,3,4,5,67]} by Fmoc SPPS. Pyrophosphate formation has been noted in peptides containing adjacent Tyr(PO₃H₂) residues ^[4,5]. An evaluation of the optimal coupling conditions for introduction of this residue has been made ^[6].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] E. A. Ottinger, et al. (1993) Biochemistry, 32, 4354.
^[2] E. A. Ottinger, et al. (1995) Int. J. Peptide Protein Res., 46, 346.
^[3] F. Anjuere, et al. (1995) Anal. Biochem., 229, 61.
^[4] C. Garcia-Echeverria (1995) Lett. Pept. Sci., 2, 93.
^[5] R. M. Valerio, et al. (1995) Lett. Pept. Sci., 2, 33.
^[6] C. Garcia-Echeverria (1996) Lett. Pept. Sci., 2, 369.
^[7] L. F. Bonewald, et al. (1999) J. Peptide Res., 53, 161.

Liaison

Replaces: 04-12-1125

Remarque sur l'analyse

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(CMA1)): ≥ 95 %
Purity (TLC(0110)): ≥ 95 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 85.0 %
Water (K. F.): ≤ 2.0 %
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.1 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable