658395

AG 18

A broad-spectrum protein tyrosine kinase inhibitor.

• Synonyme(s) : AG 18, α-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810
• Formule empirique (notation de Hill): C₁₀H₆N₂O₂
• Numéro CAS: 118409-57-7
• Poids moléculaire : 186.17
• Numéro MDL: MFCD00133899
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: yellow
• Solubilité: DMSO: 100 mg/mL; ethanol: 50 mg/mL; acetic acid: soluble
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H
• Clé InChI: VTJXFTPMFYAJJU-UHFFFAOYSA-N

Description

Description générale

A broad-spectrum protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC₅₀ = 40 µM) and the GTPase activity of transducin (IC₅₀ = 10 µM). Inhibits aldosterone secretion in response to Angiotensin II (Cat. No. 05-23-0101). Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini.

A cell-permeable, reversible, substrate competitive protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC₅₀ = 40 µM) and the GTPase activity of transducin (IC₅₀ = 10 µM). Inhibits aldosterone secretion in response to angiotensin II. Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini. Also reported to inhibit guanylyl cyclase.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
epidermal growth factor receptor autophosphorylation

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 40 µM against epidermal growth factor receptor autophosphorylation; 10 µM against GTPase activity of transducin

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Autres remarques

Jaleel, M., et al. 2004. Biochemistry43, 8247.
Kapas, S., et al. 1995. Biochem. J. 305, 433.
Seger, R., et al. 1995. J. Biol. Chem.270, 28325.
Williams, J.A. 1994. Am. J. Physiol.267, G401.
Geissler, J.F., et al. 1990. J. Biol. Chem.265, 22255.
Levitzki, A. 1990. Biochem. Pharmacol.40, 913.
Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable