580556

Paclitaxel, Semi-Synthetic

A semi-synthetic form of Paclitaxel having no contamination by natural taxanes. Also has reduced levels of epimerization products as contaminants.

• Synonyme(s) : Paclitaxel, Semi-Synthetic
• Formule empirique (notation de Hill): C₄₇H₅₁NO₁₄
• Numéro CAS: 33069-62-4
• Poids moléculaire : 853.91
• Numéro MDL: MFCD00869953
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: crystalline solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated; protect from light
• Solubilité: DMSO: soluble; methanol: soluble
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38?,40-,45+,46-,47+/m0/s1
• Clé InChI: RCINICONZNJXQF-VAZQATRQSA-N

Description

Description générale

A semi-synthetic form of Paclitaxel (Cat. No. 580555) having no contamination by natural taxanes. Also has reduced levels of epimerization products as contaminants.

A semi-synthetically derived form of Paclitaxel (TAXOL^®, Cat. No. 580555) having no contamination of natural taxanes. Also has less epimerization products as contaminants. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G₂/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Promotes assembly of microtubules and inhibits tubulin disassembly.

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Autres remarques

Derry, W.B., et al. 1995. Biochemistry 34, 2203.
Milas, L., et al. 1995. Cancer Chemother. Pharmacol.35, 297.
Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
Hornback, N.B., et al. 1994. In Vivo8, 819.
Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
Ding, A.H., et al. 1990. Science248, 370.
Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci.97, 101.
Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Taxol is a registered trademark of Bristol-Myers Squibb Co.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H341,H360FD,H372
• Conseils de prudence: P202 - P260 - P264 - P280 - P308 + P313 - P405
• Classification des risques: Muta. 2 - Repr. 1B - STOT RE 1
• Organes cibles: Central nervous system,Bone marrow,Cardio-vascular system
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable