554718

REV-ERBα Antagonist, SR8278

The REV-ERBα Antagonist, SR8278 controls the biological activity of REV-ERBα.

• Synonyme(s) : REV-ERBα Antagonist, SR8278, SR8278SR 8278
• Formule empirique (notation de Hill): C₁₈H₁₉NO₃S₂
• Numéro CAS: 101910-24-1
• Poids moléculaire : 361.48
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: >95% (HPLC)
• Forme: gum; solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white to yellow-brown
• Solubilité: DMSO: 25 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

A cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC₅₀ = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC₅₀ = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Regulatory Review (Z)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.

Autres remarques

Kojetin, D., et al. 2010, Chem Bio in press

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable