529576

PP2

≥95% (HPLC), liquid, Src protein tyrosine kinase inhibitor, Calbiochem^®

• Synonyme(s) : InSolution PP2
• Formule empirique (notation de Hill): C₁₅H₁₆ClN₅
• Poids moléculaire : 301.77
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• product name: PP2, InSolution, ≥95%, 10 mM, reversible ATP-competitive inhibitor of the Src family of protein tyrosine kinases
• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: clear colorless
• Conditions d'expédition: wet ice
• Température de stockage: −20°C

Description

Description générale

A potent and selective inhibitor of the src family of tyrosine kinases. Its action is similar to PP1. Selectively inhibits p56^lck (IC₅₀ = 4 nM), p59^fynT (IC₅₀ = 5 nM), and Hck (IC₅₀ = 5 nM) compared to other tyrosine kinases, such as EGF-R (IC₅₀ = 480 nM), JAK2 (IC₅₀ >50 µM) or ZAP-70 (IC₅₀ >100 µM). Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC₅₀ = 600 nM).

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
p56^lck

Product competes with ATP.

Reversible: yes

Target IC₅₀: 4 nM, 5 nM, 5 nM, 100 nM, against p56lck, p59fynT, Hck , and Src, respectively; 600 nM against anti-CD3-stimulated tyrosine phosphorylation of human T cells

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Irritant (B)

Forme physique

A 10 mM (1 mg/331 µl) solution of PP2 (Cat. No. 529573) in DMSO.

Reconstitution

Following initial thaw, aliquot, purge with inert gas, and freeze (-20°C).

Autres remarques

Hanke, J.H., et al. 1996. J. Biol. Chem.271, 695.



Selected Citations
Lee, J., et al. 2009. Cell Stem Cell5, 76.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Point d'éclair (°C): 87 °C - closed cup - (Dimethylsulfoxide)