526524

PIM1/2 Kinase Inhibitor VI

The PIM1/2 Kinase Inhibitor VI, also referenced under CAS 587852-28-6, controls the biological activity of PIM1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonyme(s) : PIM1/2 Kinase Inhibitor VI, (Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione, SMI-16a, SMI-16a, (Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione
• Formule empirique (notation de Hill): C₁₃H₁₃NO₃S
• Numéro CAS: 587852-28-6
• Poids moléculaire : 263.31
• Numéro MDL: MFCD31382191
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.54

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: yellow
• Solubilité: DMSO: 25 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• Chaîne SMILES: S1C(=O)NC(=O)C1=Cc2ccc(cc2)OCCC
• InChI: 1S/C13H13NO3S/c1-2-7-17-10-5-3-9(4-6-10)8-11-12(15)14-13(16)18-11/h3-6,8H,2,7H2,1H3,(H,14,15,16)
• Clé InChI: GBWOSXZUTXXXQF-UHFFFAOYSA-N

Description

Description générale

A cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor against Pim-1/2 kinases (IC₅₀ = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1α (68% inhibition of DYRK1α and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (≤18% inhibition at 5 µM). Reported to exhibit antitumor activity both in PC3 human prostate cancer cultures in vitro (IC₅₀ = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20; 50 mg/kg via daily i.p.).

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Autres remarques

Xia, Z., et al. 2009. J. Med. Chem.52, 74.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable