5.06072

IWP-2

≥99% (HPLC), liquid, Wnt antagonist, Calbiochem

• Synonyme(s) : InSolution Wnt Antagonist II, IWP-2, N-(6-Methylbenzo[d]thiazol-2-yl)-2-(4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-ylthio)acetamide, Wnt Pathway Inhibitor II InSolution, Inhibitor of Wnt Production-2, Porcn Inhibitor I InSolution, InSolution Wnt Antag
• Formule empirique (notation de Hill): C₂₂H₁₈N₄O₂S₃
• Numéro CAS: 686770-61-6
• Poids moléculaire : 466.60
• Numéro MDL: MFCD04457599
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• product name: IWP-2, InSolution, ≥99%, 10 mM in DMSO, A cell-permeable benzothiazolyl-acetamide compound, Wnt Antagonist II
• Niveau de qualité: 100
• Pureté: ≥99% (HPLC)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• Température de stockage: −70°C
• InChI: 1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)
• Clé InChI: WRKPZSMRWPJJDH-UHFFFAOYSA-N

Description

Description générale

A cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Porcn

Reversible: yes

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Forme physique

A 10 mM (5 mg/1.07 ml) sterile-filtered solution of Wnt Antagonist II, IWP-2 (Cat. No. 681671) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Warming to 60°C may be required upon initial thaw.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 188.6 °F - (refers to pure substance)
• Point d'éclair (°C): 87 °C - (refers to pure substance)