491207

Novobiocin, Sodium Salt

• Synonyme(s) : Novobiocin, Sodium Salt
• Formule empirique (notation de Hill): C₃₁H₃₅N₂O₁₁ · Na
• Numéro CAS: 1476-53-5
• Poids moléculaire : 634.61
• Code UNSPSC : 12352200

Propriétés

• Pureté: ≥90% (HPLC)
• Forme: powder
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white to yellow
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C31H35N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34,36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q-1;+1
• Clé InChI: AXOUUAINTJNFRS-UHFFFAOYSA-N

Description

Description générale

A DNA gyrase inhibitor that can be used for the production of positively supercoiled plasma DNA. Targets the nucleotide-binding site of gyrase B. Exhibits antibacterial properties. Inhibits retrovirus RNA-dependent DNA polymerases. Inhibits LPS-induced production of pro-inflammatory cytokines. Reported to act as a potent inhibitor of ADP ribosylation. Also inhibits protein synthesis and alters the phosphorylation state of several cytosolic proteins.

DNA gyrase inhibitor used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases. Also a potent inhibitor of ADP ribosylation eliminates the wild-type pMG110 plasmid from E. coli.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
retrovirus RNA-dependent DNA polymerases

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, refrigerate (4°C). Stock solutions are stable for 3 months at 4°C.

Autres remarques

Marcu, M.G., et al. 2000. J. Natl. Cancer Inst.92, 242.
Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp.42, 1911.
Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586.
Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999.
Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329.
Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302 - H317 - H319
• Conseils de prudence: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable