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428020

Sigma-Aldrich

Latrunculin B

from Latrunculia magnifica, ≥95% (HPLC), solid, actin polymerization inhibitor, Calbiochem®

Synonyme(s) :

Latrunculin B, Latrunculia magnifica

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About This Item

Formule empirique (notation de Hill):
C20H29NO5S
Numéro CAS:
76343-94-7
Poids moléculaire :
395.51
Numéro MDL:
MFCD00270879
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

product name

Latrunculin B, Latrunculia magnifica, Latrunculin B, CAS 76343-94-7, is a unique marine toxin that inhibits actin polymerization and disrupts microfilament organization. It is 10 to 100-fold more potent than cytochalasins.

Niveau de qualité

100

Pureté

≥95% (HPLC)

Forme

solid

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze

Couleur

off-white to yellow

Solubilité

DMSO: 25 mg/mL
ethanol: 25 mg/mL
methanol: 50 mg/mL

Conditions d'expédition

ambient

Température de stockage

−20°C

InChI

1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1

Clé InChI

NSHPHXHGRHSMIK-JRIKCGFMSA-N

Description générale

A structurally unique marine toxin. Inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes. 10 to 100-fold more potent than cytochalasins.
A structurally unique marine toxin. Inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes; 10 to 100-fold more potent than cytochalasins.

Actions biochimiques/physiologiques

Cell permeable: no
Primary Target
Actin polymerization
Product does not compete with ATP.
Reversible: no

Avertissement

Toxicity: Harmful (C)

Autres remarques

Spector, I., et al. 1989. Cell Motil. Cytoskeleton13, 127.
de Oliveira, C.A., and Mantovani, B. 1988. Life Sci.43, 1825.
Coue, M., et al. 1987. FEBS Lett.213, 316.
Spector, I., et al. 1983. Science219, 493.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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