420139

JAK2 Inhibitor IV

The JAK2 Inhibitor IV, also referenced under CAS 1110502-30-1, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonyme(s) : JAK2 Inhibitor IV, 3-Amino-5-(N- tert-butylsulfonamido-4-phenyl)-indazole
• Formule empirique (notation de Hill): C₁₇H₂₀N₄O₂S
• Numéro CAS: 1110502-30-1
• Poids moléculaire : 344.43
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: pale yellow
• Solubilité: ethanol: 3 mg/mL; DMSO: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C17H20N4O2S/c1-17(2,3)21-24(22,23)13-7-4-11(5-8-13)12-6-9-15-14(10-12)16(18)20-19-15/h4-10,21H,1-3H3,(H3,18,19,20)
• Clé InChI: KFJCXIOVAGJCKB-UHFFFAOYSA-N

Description

Description générale

An aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant (IC₅₀ = 78 and 206 nM, respectively) frequently found in patients with clonal polycythemia vera, essential thrombocytosis, and chronic idiopathic myelofibrosis, while exhibiting much reduced activity against JAK3 (IC₅₀ = 2.93 µM).

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Antonysamy, S., et al. 2008. Bioorg. Med. Chem. Lett.19, 279.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable