410957

3-Isobutyl-1-methylxanthine

≥98% (HPLC), solid, cAMP and cGMP phosphodiesterase inhibitor, Calbiochem^®

• Synonyme(s) : 3-Isobutyl-1-methylxanthine, IBMX
• Formule empirique (notation de Hill): C₁₀H₁₄N₄O₂
• Numéro CAS: 28822-58-4
• Poids moléculaire : 222.24
• Numéro MDL: MFCD00005584
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• product name: 3-Isobutyl-1-methylxanthine, A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀ = 2-50 µM).
• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: white
• Solubilité: ethanol: 10 mg/mL; DMSO: 100 mM; methanol: 50 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
• Clé InChI: APIXJSLKIYYUKG-UHFFFAOYSA-N

Description

Description générale

A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀ = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNF-α expression in adipocyte precursor cells.

A non-specific, cell-permeable inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀ = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNFα expression in adipocyte precursor cells.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
cAMP and cGMP phosphodiesterases

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2-50 µM against cAMP and cGMP phosphodiesterases

Avertissement

Toxicity: Standard Handling (A)

Notes préparatoires

Heating may be required to achieve complete solubilization.

Reconstitution

Following reconstitution in ethanol or methanol, refrigerate (4°C). Following reconstitution in DMSO, aliquot and freeze (-20°C). Ethanol/methanol and DMSO stock solutions are stable for up to 6 months at 4°C or -20°C, respectively.

Autres remarques

Hube, F., et al. 1999. Horm. Metab. Res.31, 359.
Morgan, A.J., et al. 1993. Biochem. Pharmacol.45, 2373.
Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci.11, 150.
Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA76, 4451.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable